Membrane compartmentation is required for efficient T cell activation.
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Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/TxkFyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeletonRecruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signalingPhosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activationA role for MHC class II antigen processing in B cell development.Cloning of ACP33 as a novel intracellular ligand of CD4Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transductionCrystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC moleculeMitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activationDifferential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in plateletsTyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector moleculesHuman CD8+ T cells do not require the polarization of lipid rafts for activation and proliferationA novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptorRegulatory and signaling properties of the Vav familyKv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cellsMembrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actinThe Nef protein of HIV-1 associates with rafts and primes T cells for activationAssociation of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transductionCbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cellsVav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activationGrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activationSpatial and temporal regulation of protein kinase D (PKD)Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranesSpecific association of glycoprotein B with lipid rafts during herpes simplex virus entryBeta1 integrins show specific association with CD98 protein in low density membranesTetraspanins and Transmembrane Adaptor Proteins As Plasma Membrane Organizers-Mast Cell CaseMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsMHC class II association with lipid rafts on the antigen presenting cell surfaceFlavivirus Activates Phosphatidylinositol 3-Kinase Signaling To Block Caspase-Dependent Apoptotic Cell Death at the Early Stage of Virus InfectionA lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylationBiochemical interactions integrating Itk with the T cell receptor-initiated signaling cascadeThe adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cellsItk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitmentCytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complexUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingLAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathwayCD3 delta establishes a functional link between the T cell receptor and CD8CD28 and CTLA-4 coreceptor expression and signal transductionA role for lipid rafts in B cell antigen receptor signaling and antigen targeting
P2860
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P2860
Membrane compartmentation is required for efficient T cell activation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Membrane compartmentation is required for efficient T cell activation.
@en
Membrane compartmentation is required for efficient T cell activation.
@nl
type
label
Membrane compartmentation is required for efficient T cell activation.
@en
Membrane compartmentation is required for efficient T cell activation.
@nl
prefLabel
Membrane compartmentation is required for efficient T cell activation.
@en
Membrane compartmentation is required for efficient T cell activation.
@nl
P2093
P1433
P1476
Membrane compartmentation is required for efficient T cell activation.
@en
P2093
P304
P356
10.1016/S1074-7613(00)80577-4
P407
P577
1998-06-01T00:00:00Z