Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).
about
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3Mechanism of regulation of the Epac family of cAMP-dependent RapGEFsDirect binding of p130(Cas) to the guanine nucleotide exchange factor C3GLocal activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizesThe Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogasterStructure of the small G protein Rap2 in a non-catalytic complex with GTPStructure of the Dominant Negative S17N Mutant of Ras ,NSP-Cas protein structures reveal a promiscuous interaction module in cell signalingRalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for RalSignaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKLA fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonistsRap1 activation is required for Fc gamma receptor-dependent phagocytosisHigh glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathwayCrk activation of JNK via C3G and R-RasDomain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media?Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Adapter molecules in T cell receptor signaling.Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathwaysOn the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b.Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Rap1 and Rap2 antagonistically control endothelial barrier resistance.The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo.Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activitiesImpaired fertility and spermiogenetic disorders with loss of cell adhesion in male mice expressing an interfering Rap1 mutant.The small GTPase, Rap1, mediates CD31-induced integrin adhesion.Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs.Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosisThe Ras mutant D119N is both dominant negative and activated.Rap1 mutants with increased affinity for the guanine-nucleotide exchange factor C3G.Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.Sequential regulation of the small GTPase Rap1 in human platelets.Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.
P2860
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P2860
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Biochemical characterization o ...... and is not inhibited by Rap1A
@nl
Biochemical characterization o ...... not inhibited by Rap1A(S17N).
@en
type
label
Biochemical characterization o ...... and is not inhibited by Rap1A
@nl
Biochemical characterization o ...... not inhibited by Rap1A(S17N).
@en
prefLabel
Biochemical characterization o ...... and is not inhibited by Rap1A
@nl
Biochemical characterization o ...... not inhibited by Rap1A(S17N).
@en
P2093
P356
P1433
P1476
Biochemical characterization o ...... not inhibited by Rap1A(S17N).
@en
P2093
Wittinghofer A
van den Berghe N
P2888
P304
P356
10.1038/SJ.ONC.1201407
P407
P577
1997-08-01T00:00:00Z