Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells
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C/EBPα Dysregulation in AML and ALLNucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell sizeRepression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexesPrevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology GroupUpstream open reading frames: molecular switches in (patho)physiologyCell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemiaA CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repairMolecular landscape of acute myeloid leukemia in younger adults and its clinical relevanceTribbles in normal and malignant haematopoiesisThe Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia TherapyEngineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic MalignanciesA SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesisReduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basisThe European Hematology Association Roadmap for European Hematology Research: a consensus documentUsing cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation.A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes.Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemiaDisruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AMLThe biological effects of C/EBPalpha in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain.Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cellsPhosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiationTransformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 bindingThe multifaceted functions of C/EBPα in normal and malignant haematopoiesis.C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutationsCharacterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia.Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cellsBiology, risk stratification, and therapy of pediatric acute leukemias: an update.C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes.Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq.CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinomaNon-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.
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Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells
description
article
@en
im April 2008 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2008
@uk
name
Modeling of C/EBPα Mutant Acut ...... loid Leukemia-Initiating Cells
@en
Modeling of C/EBPα Mutant Acut ...... loid Leukemia-Initiating Cells
@nl
type
label
Modeling of C/EBPα Mutant Acut ...... loid Leukemia-Initiating Cells
@en
Modeling of C/EBPα Mutant Acut ...... loid Leukemia-Initiating Cells
@nl
prefLabel
Modeling of C/EBPα Mutant Acut ...... loid Leukemia-Initiating Cells
@en
Modeling of C/EBPα Mutant Acut ...... loid Leukemia-Initiating Cells
@nl
P2093
P50
P1433
P1476
Modeling of C/EBPalpha mutant ...... loid leukemia-initiating cells
@en
P2093
Claus Nerlov
Evelin Schrock
Susan Moore
Thomas A Pedersen
Thomas Pabst
P304
P356
10.1016/J.CCR.2008.02.008
P50
P577
2008-04-01T00:00:00Z