The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.
about
Systematic identification of regulatory proteins critical for T-cell activationCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonDifferential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in plateletsActin dynamics in plateletsGPVI and integrin alphaIIb beta3 signaling in plateletsSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondIntegrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsAdaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domainRhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formationRac1 is essential for platelet lamellipodia formation and aggregate stability under flow.SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristicsPlatelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.Role for ADAP in shear flow-induced platelet mechanotransduction.GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.The role of the adapter molecule SLP-76 in platelet function.Positive and negative regulation of T-cell activation by adaptor proteins.Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton.The TCR ADAPts to integrin-mediated cell adhesion.Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets.Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells.Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.SLP-76 couples Syk to the osteoclast cytoskeletonFuture innovations in anti-platelet therapies.Compartmentalization of ITAM and integrin signaling by adapter molecules.Convergence of immunoreceptor and integrin signaling.Platelet integrins and immunoreceptors.Integrin signalling and function in immune cells.Rho GTPases in platelet functionIntegrin αIIbβ3 outside-in signaling.Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets.Antiplatelet therapy: present status and future prospects.The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIaT-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation.Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant.Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.Involvement of Src kinases and PLCgamma2 in clot retraction.
P2860
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P2860
The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The molecular adapter SLP-76 r ...... ta3 to the actin cytoskeleton.
@ast
The molecular adapter SLP-76 r ...... ta3 to the actin cytoskeleton.
@en
type
label
The molecular adapter SLP-76 r ...... ta3 to the actin cytoskeleton.
@ast
The molecular adapter SLP-76 r ...... ta3 to the actin cytoskeleton.
@en
prefLabel
The molecular adapter SLP-76 r ...... ta3 to the actin cytoskeleton.
@ast
The molecular adapter SLP-76 r ...... ta3 to the actin cytoskeleton.
@en
P2093
P2860
P356
P1476
The molecular adapter SLP-76 r ...... eta3 to the actin cytoskeleton
@en
P2093
A Obergfell
G A Koretzky
S J Shattil
P2860
P304
P356
10.1074/JBC.M010639200
P407
P577
2000-12-11T00:00:00Z