about
Chimeric RNase H-competent oligonucleotides directed to the HIV-1 Rev response elementTranslation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotidesEukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domainTherapeutic Oligonucleotides Targeting Liver Disease: TTR AmyloidosisThe absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair.Replication stress in Mammalian cells and its consequences for mitosisGenomic analysis of wig-1 pathwaysDetermination of optimal sites of antisense oligonucleotide cleavage within TNFalpha mRNA.Human RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processingEukaryotic ribonucleases HI and HII generate characteristic hydrolytic patterns on DNA-RNA hybrids: further evidence that mitochondrial RNase H is an RNase HII.Programmable RNA recognition and cleavage by CRISPR/Cas9.The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides.Human RNase H1 activity is regulated by a unique redox switch formed between adjacent cysteines.Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.Potential roles of antisense technology in cancer chemotherapy.Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.RNA-based gene therapy for HIV infection.Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease HA type II ribonuclease H from Leishmania mitochondria: an enzyme essential for the growth of the parasite.U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNPBCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia.Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms.Probe-Directed Degradation (PDD) for Flexible Removal of Unwanted cDNA Sequences from RNA-Seq Libraries.Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's diseaseA randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis.RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications.Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein InteractionsRational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.Antisense Oligonucleotides: Treatment Strategies and Cellular Internalization.2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.Systematic analysis of the role of target site accessibility in the activity of DNA enzymes.A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells.Design of antisense oligonucleotides stabilized by locked nucleic acids.Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridines.Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells.The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.Evidence for a dual functional role of a conserved histidine in RNA·DNA heteroduplex cleavage by human RNase H1.Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage.Influence of mismatched and bulged nucleotides on SNP-preferential RNase H cleavage of RNA-antisense gapmer heteroduplexes.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Properties of cloned and expressed human RNase H1.
@ast
Properties of cloned and expressed human RNase H1.
@en
type
label
Properties of cloned and expressed human RNase H1.
@ast
Properties of cloned and expressed human RNase H1.
@en
prefLabel
Properties of cloned and expressed human RNase H1.
@ast
Properties of cloned and expressed human RNase H1.
@en
P2093
P2860
P356
P1476
Properties of cloned and expressed human RNase H1.
@en
P2093
P2860
P304
28270-28278
P356
10.1074/JBC.274.40.28270
P407
P577
1999-10-01T00:00:00Z