Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.
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Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotidesAdvanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the BrainNanoparticle-based targeted therapeutics in head-and-neck cancerAntisense oligonucleotides: treating neurodegeneration at the level of RNASynthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNANovel complex MAD phasing and RNase H structural insights using selenium oligonucleotidesRibonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotidesSilencing disease genes in the laboratory and the clinicHuman RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processingChemical modification: the key to clinical application of RNA interference?Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides.The notorious R.N.A. in the spotlight - drug or target for the treatment of diseaseNon-coding RNAs: a key to future personalized molecular therapy?Oligonucleotide-based strategies to combat polyglutamine diseases.The clinical potential of microRNAsTherapeutic RNA manipulation in liver disease.Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.Targeting of repeated sequences unique to a gene results in significant increases in antisense oligonucleotide potency.Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.Clinical and preclinical pharmacokinetics and pharmacodynamics of mipomersen (kynamro(®)): a second-generation antisense oligonucleotide inhibitor of apolipoprotein BTargeting nuclear RNA for in vivo correction of myotonic dystrophyA phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis.Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver functionPeptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissueEffects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteersMechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes.Towards a therapy for Angelman syndrome by targeting a long non-coding RNA.Defining the factors that contribute to on-target specificity of antisense oligonucleotides.Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms.MicroRNAs and Gastroenterological Cancers.Hematologic malignancies: newer strategies to counter the BCL-2 protein.A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5'UTRs of Selected Tumor Suppressors.Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.Antisense therapy for cancer.In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.Antisense oligonucleotides as therapeutics for hyperlipidaemias.Antisense-based cancer therapeutics: are we there yet?Crystallization and preliminary crystallographic analysis of type 1 RNase H from the hyperthermophilic archaeon Sulfolobus tokodaii 7.Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides.
P2860
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P2860
Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Determination of the role of t ...... y of DNA-like antisense drugs.
@ast
Determination of the role of t ...... y of DNA-like antisense drugs.
@en
Determination of the role of t ...... y of DNA-like antisense drugs.
@nl
type
label
Determination of the role of t ...... y of DNA-like antisense drugs.
@ast
Determination of the role of t ...... y of DNA-like antisense drugs.
@en
Determination of the role of t ...... y of DNA-like antisense drugs.
@nl
prefLabel
Determination of the role of t ...... y of DNA-like antisense drugs.
@ast
Determination of the role of t ...... y of DNA-like antisense drugs.
@en
Determination of the role of t ...... y of DNA-like antisense drugs.
@nl
P2093
P2860
P356
P1476
Determination of the role of t ...... y of DNA-like antisense drugs.
@en
P2093
Hong Zhang
Hongjiang Wu
Stanley T Crooke
Walt F Lima
P2860
P304
17181-17189
P356
10.1074/JBC.M311683200
P407
P577
2004-02-11T00:00:00Z