Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. - sprookjes - yvandenbroek - TriplyDB

Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.

Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.

http://www.wikidata.org/entity/Q46503099

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Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation Mechanisms of HIV protein degradation into epitopes: implications for vaccine design Antigenic peptide trimming by ER aminopeptidases--insights from structural studies What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1 A Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional Specialization IRAP identifies an endosomal compartment required for MHC class I cross-presentation ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci Bimodal distribution of RNA expression levels in human skeletal muscle tissue.Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.A detailed analysis of the murine TAP transporter substrate specificity The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Pathways of antigen processing.ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1 The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2.Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure.Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma Update on ankylosing spondylitis: current concepts in pathogenesis.Diversity of natural self-derived ligands presented by different HLA class I molecules in transporter antigen processing-deficient cells.Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

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P2860

Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.

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2005 nî lūn-bûn

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Nature Immunology

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Fiona Greer

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Gabriele Niedermann

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Lutz Schomburg

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Oliver Carroll

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Vivian Lindo

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P2860

Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells

Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases

Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding

Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues

An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides

The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

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10.1038/NI1208

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7

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Peter M van Endert

Yves Lepelletier

Margarita Del Val

Loredana Saveanu

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2005-05-22T00:00:00Z

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7832561

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15908954

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endoplasmic reticulum