GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
about
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityLRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site statusFunctional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyActivation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainmTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1G2385R and I2020T Mutations Increase LRRK2 GTPase ActivityProtective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegenerationArsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistributionThe Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.LRRK2: an éminence grise of Wnt-mediated neurogenesis?Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic NeurotransmissionContribution of GTPase activity to LRRK2-associated Parkinson diseasePrediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesisGenetic, structural, and molecular insights into the function of ras of complex proteins domains.LRRK2 pathobiology in Parkinson's disease.Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.LRRK2 and the Immune System.Regulation of LRRK2 promoter activity and gene expression by Sp1.Mechanisms of Mutant LRRK2 Neurodegeneration.New developments in genetic rat models of Parkinson's disease.Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.The Enzymatic Core of the Parkinson’s Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.
P2860
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P2860
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
GTPase activity regulates kina ...... son's disease-associated LRRK2
@ast
GTPase activity regulates kina ...... son's disease-associated LRRK2
@en
GTPase activity regulates kina ...... son's disease-associated LRRK2
@en-gb
GTPase activity regulates kina ...... son's disease-associated LRRK2
@nl
type
label
GTPase activity regulates kina ...... son's disease-associated LRRK2
@ast
GTPase activity regulates kina ...... son's disease-associated LRRK2
@en
GTPase activity regulates kina ...... son's disease-associated LRRK2
@en-gb
GTPase activity regulates kina ...... son's disease-associated LRRK2
@nl
prefLabel
GTPase activity regulates kina ...... son's disease-associated LRRK2
@ast
GTPase activity regulates kina ...... son's disease-associated LRRK2
@en
GTPase activity regulates kina ...... son's disease-associated LRRK2
@en-gb
GTPase activity regulates kina ...... son's disease-associated LRRK2
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
GTPase activity regulates kina ...... son's disease-associated LRRK2
@en
P2093
Alice Biosa
Darren J Moore
Laura Civiero
Liliane Glauser
P2860
P304
P3181
P356
10.1093/HMG/DDS522
P407
P577
2013-03-15T00:00:00Z