DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms - Wikidata - awgldk - TriplyDB

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

http://www.wikidata.org/entity/Q24643052

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Associating schizophrenia, long non-coding RNAs and neurostructural dynamics RNA Sequencing in Schizophrenia Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation.DISC1 at 10: connecting psychiatric genetics and neuroscience DISC1-binding proteins in neural development, signalling and schizophrenia DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.Allele-specific regulation of DISC1 expression by miR-135b-5p Gene processing control loops suggested by sequencing, splicing, and RNA folding.The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.Prenatal expression patterns of genes associated with neuropsychiatric disorders.Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain.Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi.Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.Linking neurodevelopmental and synaptic theories of mental illness through DISC1 The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.Genetic neuropathology of obsessive psychiatric syndromes.Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders.Psychiatric brain banking: three perspectives on current trends and future directions.DISC1 is associated with cortical thickness and neural efficiency Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents.Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.Elevated DISC1 transcript levels in PBMCs during acute psychosis in patients with schizophrenia.Half-life of DISC1 protein and its pathological significance under hypoxia stress Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia Interactions of human truncated DISC1 proteins: implications for schizophrenia.SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia.A structure-function mechanism for schizophrenia.

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P2860

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

http://www.wikidata.org/entity/Q24643052

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

DISC1 splice variants are upre ...... ciated with risk polymorphisms

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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type

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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prefLabel

DISC1 splice variants are upre ...... ciated with risk polymorphisms

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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PNAS.0903413106

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Proceedings of the National Academy of Sciences of the United States of America

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DISC1 splice variants are upre ...... ciated with risk polymorphisms

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Barbara K Lipska

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Erin N Newburn

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Joel E Kleinman

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Kenji Nakata

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Maxim Barenboim

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Radhakrishna Vakkalanka

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Thomas M Hyde

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Tianzhang Ye

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Yoshitatsu Sei

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Yukitaka Morita

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P2860

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.

Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth

Distinct roles for Arp2/3 regulators in actin assembly and endocytosis

Alternative isoform regulation in human tissue transcriptomes

Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22

Disruption of two novel genes by a translocation co-segregating with schizophrenia

Yeast two-hybrid screens implicate DISC1 in brain development and function

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10.1073/PNAS.0903413106

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37

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106

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Daniel R. Weinberger

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2009-09-15T00:00:00Z

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26871405

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