Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells.
about
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase familyStructural basis of substrate discrimination and integrin binding by autotaxinLysophosphatidic acid production and action: critical new players in breast cancer initiation and progressionReceptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cellsL-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxinThe emerging role of FTY720 (Fingolimod) in cancer treatmentThe hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic siteInhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphateDifferential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte traffickingIL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and PC-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (RA)Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrestExocrine pancreatic carcinogenesis and autotaxin expressionStructural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatasesSynthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cellsCancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclastsNovel point mutations attenuate autotaxin activityBiological roles of lysophospholipid receptors revealed by genetic null mice: an update.Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration.Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model.Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma.Molecular signatures of metastasis in head and neck cancer.beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous woundsSynergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling.Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosisAutotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesotheliaLigand-based autotaxin pharmacophore models reflect structure-based docking results.c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomasChemical evolution of autotaxin inhibitorsAutotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivoAutotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progressionCarba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasisAltered gene and protein expression by Nm23-H1 in metastasis suppression.Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cellsAberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer.Cyclic phosphatidic acid - a unique bioactive phospholipid.
P2860
Q24298713-CC3FE195-9C4B-4EFE-9D11-BA8BB03D635AQ24337236-431ACAC5-2D3D-42CE-9183-B223B0E5C893Q24616764-4AA10A58-35E6-4A58-B9A4-E71B84B55961Q24792463-E023E29C-06DB-4EFA-8454-6DAC357B5FF8Q24800365-F6E665C8-3D07-4593-B04A-22FEC22C7F4EQ26748927-BCD786B3-CA35-453B-ABC6-47BAAD7457FAQ28182672-C97490B6-158C-4BCD-BDED-6FD0CE22ABE0Q28239967-3C9D429C-410B-49D7-8C98-79DFC2E028B1Q28242325-93A5329A-5FB8-47B9-A21F-942F2F8F6EE6Q28347268-3BE11884-D575-42A0-81DE-799306D30D94Q28478339-E5C003C1-E094-4A62-8C23-D7479187F4D3Q28482954-99F320DD-CC39-4419-8B2F-80A2F0B0040BQ28590714-BEC8B014-0E44-4087-BD9B-AF319A0913C1Q30411650-FA3D5473-0A93-4E79-A60B-025DB2B308A1Q30434740-E13D3EF9-11F4-4530-87CA-CE0140689836Q30434947-EFA5D1D9-71EA-4DD1-9411-BD6E8DDB507CQ30436718-6F6D2352-5491-4DBC-A411-A108F4825D4BQ30440170-D0797657-1958-4461-BCB5-920B208C7031Q30487082-F2714F2D-A648-4923-AAE8-440D8B35F97FQ33548625-298B971E-0032-473B-ADEA-5CF4B9C5E5C5Q33739306-65817A1B-2DAD-4845-AA3F-4E2D1B77C504Q33759458-948B6313-0C7E-4F29-9E74-9DCB8988ACB3Q33842405-E5731BE5-E357-4E51-B21A-9B1E4F1B83F7Q34060131-0191E9C2-29CF-4999-9CBA-1EED7F930831Q34068062-D9FB48C2-CDA8-4FCB-8CB5-AB6225B1E7F2Q34113095-EC0464F7-4F63-4AC2-9AE5-CB61AFB89A6BQ34642602-3385FDE0-1E79-442E-911F-56A1F9237A9EQ34660049-08243627-7AEE-481E-AA75-341CF053E484Q34920997-A6746F94-8F41-451F-AE22-D4C14DF7F4F6Q35575527-BC2EEF38-5619-4840-8F0B-B4341455665AQ35756057-95ACD7F2-6411-4E5E-8281-4091B838E3C8Q35949924-C40E57FE-7353-4611-9596-B10D75C992E1Q36175446-9A108583-496B-42E7-9B5C-CB4D9DCE81B3Q36246828-7A63E7FA-A16F-4E0C-BF31-158740ABB275Q36399256-D0AC2D3C-4266-4F68-8C48-23435628215FQ36421116-63EF5790-CD82-4ED3-8407-BE7622DB883BQ36445269-4A300CC8-8549-4744-9206-02FA4D9FDC74Q36742070-79458AB6-8333-4B78-89A7-6647027D6E25Q36820509-16016DB6-14A1-45A6-A19F-40DB411CD1AAQ36947041-EB2B7D45-F9E2-49EC-ACEE-FD5C146CE447
P2860
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Autotaxin (ATX), a potent tumo ...... tial of ras-transformed cells.
@en
type
label
Autotaxin (ATX), a potent tumo ...... tial of ras-transformed cells.
@en
prefLabel
Autotaxin (ATX), a potent tumo ...... tial of ras-transformed cells.
@en
P2093
P2860
P356
P1433
P1476
Autotaxin (ATX), a potent tumo ...... tial of ras-transformed cells.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203263
P407
P577
2000-01-01T00:00:00Z
P5875
P6179
1003696605