Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase
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Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7Targeting p97 to Disrupt Protein Homeostasis in CancerAsymmetric ring structure of Vps4 required for ESCRT-III disassembly.A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutantsAltered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 MutantsRlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturationFundamental Characteristics of AAA+ Protein Family Structure and FunctionMutations in the Human AAA+ Chaperone p97 and Related DiseasesNucleotide-dependent conformational changes of the AAA+ ATPase p97 revisitedAltered cofactor regulation with disease-associated p97/VCP mutationsControl of p97 function by cofactor bindingCovalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell deathThe AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnoverPositive cooperativity of the p97 AAA ATPase is critical for essential functionsRoles of conserved arginines in ATP-binding domains of AAA+ chaperone ClpB from Thermus thermophilusProtein structure determination by exhaustive search of Protein Data Bank derived databasesA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domainsFunctional chromatography reveals three natural products that target the same protein with distinct mechanisms of action.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?The complexities of p97 function in health and diseaseA Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.The power of AAA-ATPases on the road of pre-60S ribosome maturation--molecular machines that strip pre-ribosomal particlesDistinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyThe ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment.Simulations of the p97 complex suggest novel conformational states of hydrolysis intermediatesInhibitors of the AAA+ chaperone p97Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.Structural and functional deviations in disease-associated p97 mutants.Motor mechanism for protein threading through Hsp104.Membrane protein targeting to the MVB/lysosome.A nucleolar AAA-NTPase is required for parasite division.ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97.The role of bacterial enhancer binding proteins as specialized activators of σ54-dependent transcriptionEmerging mechanistic insights into AAA complexes regulating proteasomal degradation.Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy.Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine.Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.Arsenic Compromises Both p97 and Proteasome Functions.Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes.
P2860
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P2860
Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase
description
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
@ast
im Mai 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/05/16)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/05/16)
@nl
наукова стаття, опублікована в травні 2008
@uk
name
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@ast
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@en
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@nl
type
label
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@ast
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@en
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@nl
prefLabel
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@ast
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@en
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@nl
P2093
P2860
P3181
P356
P1476
Analysis of nucleotide binding ...... a tandem AAA hexameric ATPase
@en
P2093
Geoff S. Baldwin
Hisao Kondo
Louise C. Briggs
Non Miyata
Paul S. Freemont
P2860
P304
13745–13752
P3181
P356
10.1074/JBC.M709632200
P407
P577
2008-05-16T00:00:00Z