DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
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Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesisPlxdc2 is a mitogen for neural progenitorsDNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutationM17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in miceAn overview of Y-Family DNA polymerases and a case study of human DNA polymerase ηThe Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationPostreplication gaps at UV lesions are signals for checkpoint activation.The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.RMRP is a non-coding RNA essential for early murine development.AID and somatic hypermutation.Controlling somatic hypermutation in immunoglobulin variable and switch regions.Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet lightTranslesion DNA polymerasesDNA polymerases and somatic hypermutation of immunoglobulin genesMSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaksMouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleusImmunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.What a difference a decade makes: insights into translesion DNA synthesis.HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligaseDNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturationEvaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repairContribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouseAntibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerasesReplication-independent repair of DNA interstrand crosslinksReevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.DNA polymerases and cancer.Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.Hijacked DNA repair proteins and unchained DNA polymerases.Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity.Polk mutant mice have a spontaneous mutator phenotype.A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions.
P2860
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P2860
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
description
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im November 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/11/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/11/01)
@nl
наукова стаття, опублікована в листопаді 2002
@uk
مقالة علمية (نشرت في نوفمبر 2002)
@ar
name
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@ast
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@en
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@nl
type
label
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@ast
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@en
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@nl
prefLabel
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@ast
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@en
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@nl
P2093
P1476
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
@en
P2093
Caixia Guo
Charles L. White
Christa L. Hladik
Dominik Schenten
Errol C. Friedberg
Gloria Esposito
Susana Velasco-Miguel
Valerie L. Gerlach
P304
P356
10.1002/1521-4141(200211)32:113.0.CO;2-2
P407
P577
2002-11-01T00:00:00Z