Polk mutant mice have a spontaneous mutator phenotype. - Wikidata - awgldk - TriplyDB

Polk mutant mice have a spontaneous mutator phenotype.

Polk mutant mice have a spontaneous mutator phenotype.

http://www.wikidata.org/entity/Q37455758

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Role of DNA polymerase κ in the maintenance of genomic stability Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability.Structural and dynamic characterization of polymerase κ's minor groove lesion processing reveals how adduct topology impacts fidelity.Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions Bypass of N²-ethylguanine by human DNA polymerase κ.Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks The fork and the kinase: a DNA replication tale from a CHK1 perspective.Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.DNA polymerases and cancer.Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct.Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.Mouse models of DNA polymerases.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.Translesion Synthesis DNA Polymerase Kappa Is Indispensable for DNA Repair Synthesis in Cisplatin Exposed Dorsal Root Ganglion Neurons.Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA.Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone.Translesion synthesis polymerases in the prevention and promotion of carcinogenesis.Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene-induced genotoxicity in vivo.Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism.

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P2860

Polk mutant mice have a spontaneous mutator phenotype.

http://www.wikidata.org/entity/Q37455758

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 26 September 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Polk mutant mice have a spontaneous mutator phenotype.

@en

Polk mutant mice have a spontaneous mutator phenotype.

@nl

type

label

Polk mutant mice have a spontaneous mutator phenotype.

@en

Polk mutant mice have a spontaneous mutator phenotype.

@nl

prefLabel

Polk mutant mice have a spontaneous mutator phenotype.

@en

Polk mutant mice have a spontaneous mutator phenotype.

@nl

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P356

J.DNAREP.2009.09.003

P1433

P1476

Polk mutant mice have a spontaneous mutator phenotype.

@en

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Caixia Guo

http://www.w3.org/2001/XMLSchema#string

Errol C Friedberg

http://www.w3.org/2001/XMLSchema#string

J Nicole Kosarek Stancel

http://www.w3.org/2001/XMLSchema#string

James Richardson

http://www.w3.org/2001/XMLSchema#string

Lisa D McDaniel

http://www.w3.org/2001/XMLSchema#string

Susana Velasco

http://www.w3.org/2001/XMLSchema#string

P2860

Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice

DNA polymerase kappa deficiency does not affect somatic hypermutation in mice

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa.

Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene

Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice.

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota

Suffering in silence: the tolerance of DNA damage.

Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.

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1355-1362

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scholarly article

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10.1016/J.DNAREP.2009.09.003

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12

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8

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2009-09-26T00:00:00Z

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26840058

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19783230

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2787749

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