Regulation of LRRK2 expression points to a functional role in human monocyte maturation
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Insights into Neuroinflammation in Parkinson's Disease: From Biomarkers to Anti-Inflammatory Based TherapiesThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseLRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseM1 and M2 immune activation in Parkinson's Disease: Foe and ally?Parkinson's disease and immune system: is the culprit LRRKing in the periphery?The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signalingLRRK2 levels in immune cells are increased in Parkinson's diseaseAbrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.Leucine-rich α2-glycoprotein is a novel biomarker of neurodegenerative disease in human cerebrospinal fluid and causes neurodegeneration in mouse cerebral cortexLeucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem CellsLRRK2 inhibition attenuates microglial inflammatory responsesLeucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic CellsHuman leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesisFunction and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyondNew insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation.Cellular processes associated with LRRK2 function and dysfunctionMicroRNA expression profiling of human blood monocyte subsets highlights functional differences.Leucine-rich repeat kinase 2 and Parkinson's disease.LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.LRRK2 and the Immune System.LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.Immune responses in Parkinson's disease: interplay between central and peripheral immune systems.Computational analysis of the LRRK2 interactome.LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.TGF-β1-Induced Epithelial-Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells.Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.LRRK2 secretion in exosomes is regulated by 14-3-3.LRRK2 contributes to monocyte dysregulation in Parkinson's disease.Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.LRRK2 and human disease: a complicated question or a question of complexes?Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
P2860
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P2860
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@ast
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@en
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@nl
type
label
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@ast
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@en
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@nl
prefLabel
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@ast
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@en
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@nl
P2093
P2860
P3181
P1433
P1476
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
@en
P2093
Christoph Wiessner
Jonathan Thévenet
Robertus Hooft van Huijsduijnen
Rosanna Pescini Gobert
Yves Jean Sagot
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0021519
P407
P577
2011-01-01T00:00:00Z