Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body
about
Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-IIATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol traffickingIdentification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificitiesTSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomesMammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugatesPIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesisVHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargoThe identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunitThe mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth diseaseRole of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagyHrs regulates multivesicular body formation via ESCRT recruitment to endosomesPtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomesTransport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitinationBinding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motifATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuolesThe role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cellsESCRT requirements for EIAV buddingRegulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.Autophagy in the eukaryotic cellCellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteinsThe Phox homology (PX) domain, a new player in phosphoinositide signallingHrs recruits clathrin to early endosomesThe phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegansA mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activityThe ESCRT complexesBro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeastLocalization of phosphatidylinositol 3-phosphate in yeast and mammalian cellsBiogenesis and function of multivesicular bodiesMVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in betweenA selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell deathHuman VPS34 is required for internal vesicle formation within multivesicular endosomesNo strings attached: the ESCRT machinery in viral budding and cytokinesisRegulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositidesStructural and functional organization of the ESCRT-I trafficking complexFab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptorsThe C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
P2860
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P2860
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Fab1p PtdIns(3)P 5-kinase func ...... ing in the multivesicular body
@ast
Fab1p PtdIns(3)P 5-kinase func ...... ing in the multivesicular body
@en
type
label
Fab1p PtdIns(3)P 5-kinase func ...... ing in the multivesicular body
@ast
Fab1p PtdIns(3)P 5-kinase func ...... ing in the multivesicular body
@en
prefLabel
Fab1p PtdIns(3)P 5-kinase func ...... ing in the multivesicular body
@ast
Fab1p PtdIns(3)P 5-kinase func ...... ing in the multivesicular body
@en
P3181
P1433
P1476
Fab1p PtdIns(3)P 5-kinase func ...... ing in the multivesicular body
@en
P304
P3181
P356
10.1016/S0092-8674(00)81707-9
P407
P577
1998-12-01T00:00:00Z