Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques.
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Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifsStructure--function relationships in HIV-1 Nef.Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complexA hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.The HIV-1 Nef protein as a target for antiretroviral therapy.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques.HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution.Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.Regions of human immunodeficiency virus type 1 nef required for function in vivoRole of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaquesDesign and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation.Meta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progressionHuman immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism.CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivoTwo elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylationDynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.PAK1 as a therapeutic target.CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection.Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivoMechanisms of HIV-1 Nef function and intracellular signaling.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo.Effect of the attenuating deletion and of sequence alterations evolving in vivo on simian immunodeficiency virus C8-Nef function.Altered plaque formation by recombinant vaccinia virus expressing simian immunodeficiency virus Nef.Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1.The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques.Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDSSimian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques.Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens.Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.
P2860
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P2860
Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques.
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Association of simian immunode ...... nt of AIDS in rhesus macaques.
@ast
Association of simian immunode ...... nt of AIDS in rhesus macaques.
@en
type
label
Association of simian immunode ...... nt of AIDS in rhesus macaques.
@ast
Association of simian immunode ...... nt of AIDS in rhesus macaques.
@en
prefLabel
Association of simian immunode ...... nt of AIDS in rhesus macaques.
@ast
Association of simian immunode ...... nt of AIDS in rhesus macaques.
@en
P2093
P2860
P356
P1433
P1476
Association of simian immunode ...... nt of AIDS in rhesus macaques.
@en
P2093
Hunsmann G
Iafrate AJ
Kirchhoff F
Nisslein T
Skowronski J
Stahl-Hennig C
P2860
P2888
P304
P356
10.1038/NM0897-860
P407
P577
1997-08-01T00:00:00Z