Automated microscope system for determining factors that predict neuronal fate. - Wikidata - awgldk - TriplyDB

Automated microscope system for determining factors that predict neuronal fate.

Automated microscope system for determining factors that predict neuronal fate.

http://www.wikidata.org/entity/Q30856679

about

Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease Proceedings: consideration of genetics in the design of induced pluripotent stem cell-based models of complex disease Cell-based screening: extracting meaning from complex data.Aggresome formation and neurodegenerative diseases: therapeutic implications High-throughput screening in primary neurons IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis.Extended Field Laser Confocal Microscopy (EFLCM): combining automated Gigapixel image capture with in silico virtual microscopy Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.Towards A Fully Automated High-Throughput Phototransfection System.A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.Identifying polyglutamine protein species in situ that best predict neurodegeneration Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.The potential of high-content high-throughput microscopy in drug discovery.Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models Drug discovery in Parkinson's disease-Update and developments in the use of cellular models.Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases.Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease.Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.High-content screening of primary neurons: ready for prime time.Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.Protein aggregates in Huntington's disease.Proteostasis and aging.Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.High content screening in neurodegenerative diseases.Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast.Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Combating Parkinson's disease-associated toxicity by modulating proteostasis.

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P2860

Automated microscope system for determining factors that predict neuronal fate.

http://www.wikidata.org/entity/Q30856679

description

2005 nî lūn-bûn

@nan

2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի փետրվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Automated microscope system for determining factors that predict neuronal fate.

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Automated microscope system for determining factors that predict neuronal fate.

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type

label

Automated microscope system for determining factors that predict neuronal fate.

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Automated microscope system for determining factors that predict neuronal fate.

@en

prefLabel

Automated microscope system for determining factors that predict neuronal fate.

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Automated microscope system for determining factors that predict neuronal fate.

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PNAS.0409777102

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Automated microscope system for determining factors that predict neuronal fate

@en

P2093

Steven Finkbeiner

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P2860

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Regulation of neuronal survival by the serine-threonine protein kinase Akt

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Detection of a decrease in green fluorescent protein fluorescence for the monitoring of cell death: an assay amenable to high-throughput screening technologies.

Green fluorescent protein as a novel tool to measure apoptosis and necrosis.

Cellular diversity in the developing nervous system: a temporal view from Drosophila.

Comparison of phase-contrast and fluorescence digital autofocus for scanning microscopy.

Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system.

Strategies for the generation of neuronal diversity in the developing central nervous system.

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3840-3845

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scholarly article

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10.1073/PNAS.0409777102

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10

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102

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Montserrat Arrasate

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2005-02-28T00:00:00Z

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7996339

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15738408

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