PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis
about
Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHAMolecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Cell cycle and developmental control of hematopoiesis by Runx1.Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasisHIPK2 modulates p53 activity towards pro-apoptotic transcription.Post-translational modifications of Runx1 regulate its activity in the cellCore binding factor at the crossroads: determining the fate of the HSC.RUNX family: Regulation and diversification of roles through interacting proteins.A role for RUNX1 in hematopoiesis and myeloid leukemia.Posttranslational modifications of RUNX1 as potential anticancer targets.The RUNX family: developmental regulators in cancer.Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.Runx1 Structure and Function in Blood Cell Development.Covalent Modifications of RUNX Proteins: Structure Affects Function.Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization.HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia.Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownp300-mediated acetylation increased the protein stability of HIPK2 and enhanced its tumor suppressor function.Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.HIPK2 phosphorylates RUNX1RUNX1:CBFB binds EP300HIPK2 phosphorylates RUNX1 and EP300A novel t(7;21)(q32;q22) translocation disrupting the RUNX1 gene in an adult patient with acute myeloid leukemia.HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.HIPK2 and cancer cell resistance to therapy.
P2860
Q28541244-E7687720-3F2E-4A90-917A-9808064F3806Q30252938-BC1ABDCB-1874-40A9-B8D1-9DB2D1B655D4Q30432285-52775F61-212B-48BC-A80C-798F35C03353Q33993675-FB168921-123F-4291-88EE-FC0F54A8763BQ34063795-1F59CFE3-2993-4891-A001-FE17AC8232D5Q36206674-F60A859E-7C1F-4636-B80E-25E0DE353AE9Q36543603-EF650177-0B59-4AA1-BC66-B76A0F8D1E37Q37183604-8B3007DC-FCA5-489B-938F-2786FCB52FCCQ37201706-3C676E80-A367-4F8B-8237-CD8EEAA48F9EQ37402028-F2C88FEB-1088-47D5-B113-827120645035Q37455493-BDE6559E-C3F1-4B8D-A1BD-3E36459C29C9Q37610919-2DB27D9F-67A4-4CC3-804A-B68A822BFBE1Q38062515-87018CAE-49D6-4714-9CBF-B5C05B5C4D63Q38101285-5B60E2BB-9786-4DE8-B094-B7A1AF09A135Q38255068-CB1CA17D-DDF3-46DD-9612-7EC1289FE1F1Q38319972-EBC1F8EB-7C7B-4B00-A960-C3806B9F4E9CQ38673048-DF182E01-1145-4844-A5A0-7B52515C55E5Q38904253-4EAC95CB-B36E-4C27-BCB7-D9F64EB76716Q39181397-9ECBD414-FF97-47C0-ABC2-ADA0708D7A9EQ39654573-FE451DFC-4B43-4EAD-9F5A-55662DF53ED9Q41904978-C7C39B8C-AD9F-47CE-A58E-D2CCF18A88C9Q42020732-DD4069F6-54FE-4765-900D-B354CD860C22Q42444092-DA24F472-8C2D-4755-9246-F7DF3A11B04DQ44176860-4BB1B10A-86E5-4C44-A3BD-EFDDEAFBA58EQ45316818-E9DCFB14-BC06-49AB-AAC6-D4E45BEB9E23Q47154768-FECDF114-EBD4-4257-9157-EA0F2110A3CCQ47249032-0DF1635F-404A-4D60-B4F2-3EFCADC2ADD0Q50290623-A414A594-0527-4489-A44F-B58FCAC0B388Q50290625-852B328A-E6D8-4E8E-A359-AC1DB179624BQ50290627-2FEB9D84-8070-45F2-A3CF-40D38A16B13BQ52613700-62056E8C-2E6D-40DB-8F1B-CC945D06BF42Q54588191-93864C1D-F082-4DBB-818B-30ACFAD6817BQ54780373-0DDAEFB5-BADA-49BE-9462-8719DA6334BA
P2860
PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
PEBP2-beta/CBF-beta-dependent ...... mplications for leukemogenesis
@ast
PEBP2-beta/CBF-beta-dependent ...... mplications for leukemogenesis
@en
type
label
PEBP2-beta/CBF-beta-dependent ...... mplications for leukemogenesis
@ast
PEBP2-beta/CBF-beta-dependent ...... mplications for leukemogenesis
@en
prefLabel
PEBP2-beta/CBF-beta-dependent ...... mplications for leukemogenesis
@ast
PEBP2-beta/CBF-beta-dependent ...... mplications for leukemogenesis
@en
P2093
P2860
P921
P1433
P1476
PEBP2-beta/CBF-beta-dependent ...... mplications for leukemogenesis
@en
P2093
Dominic Chih-Cheng Voon
Hee-Jun Wee
Suk-Chul Bae
Yoshiaki Ito
P2860
P304
P356
10.1182/BLOOD-2008-01-134122
P407
P577
2008-08-11T00:00:00Z