Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. - Wikidata - awgldk - TriplyDB

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.

http://www.wikidata.org/entity/Q33244989

about

Purified human BRCA2 stimulates RAD51-mediated recombination Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51 Structural basis for recruitment of BRCA2 by PALB2 The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51 Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2 Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.Roles of C-Terminal Region of Yeast and Human Rad52 in Rad51-Nucleoprotein Filament Formation and ssDNA Annealing Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Unraveling the mechanism of BRCA2 in homologous recombination Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint Functions of alternative replication protein A in initiation and elongation Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51.BRCA2: a universal recombinase regulator.Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms.Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication.Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.Homologous recombination and its regulation Modification of the DNA damage response by therapeutic CDK4/6 inhibition.BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.Functional redundancy of exon 12 of BRCA2 revealed by a comprehensive analysis of the c.6853A>G (p.I2285V) variant Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics.The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA.BRCA1 and BRCA2: different roles in a common pathway of genome protection.A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization A second DNA binding site in human BRCA2 promotes homologous recombination The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.BRCA2: one small step for DNA repair, one giant protein purified.

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P2860

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.

http://www.wikidata.org/entity/Q33244989

description

2006 nî lūn-bûn

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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2006 թվականի մայիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Suppression of the DNA repair ...... heterologous protein fusions.

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Suppression of the DNA repair ...... heterologous protein fusions.

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type

label

Suppression of the DNA repair ...... heterologous protein fusions.

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Suppression of the DNA repair ...... heterologous protein fusions.

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prefLabel

Suppression of the DNA repair ...... heterologous protein fusions.

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Suppression of the DNA repair ...... heterologous protein fusions.

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Proceedings of the National Academy of Sciences of the United States of America

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Suppression of the DNA repair ...... heterologous protein fusions.

@en

P2093

Hiroshi Saeki

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Jeremy M Stark

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Malgorzata Z Zdzienicka

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Maria Jasin

http://www.w3.org/2001/XMLSchema#string

Mingguang Han

http://www.w3.org/2001/XMLSchema#string

Nicolas Siaud

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Nicole Christ

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Paul P W van Buul

http://www.w3.org/2001/XMLSchema#string

Wouter W Wiegant

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P2860

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

Structure of the single-strand annealing domain of human RAD52 protein

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2

Cancer susceptibility and the functions of BRCA1 and BRCA2

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103

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