The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's diseaseMKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityRac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutationsFunctional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyAn early endosome regulator, Rab5b, is an LRRK2 kinase substrateHexokinase activity is required for recruitment of parkin to depolarized mitochondriaDysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegansMutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neuronsHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsIs inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brainPathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvationInhibition of LRRK2 kinase activity stimulates macroautophagyPhosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesIdentification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motifSignal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticityPathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Parkinson's disease: insights from pathways.RNA metabolism in the pathogenesis of Parkinson׳s diseaseRecent advances in the genetics of Parkinson's disease.Leucine-rich repeat kinase 2 for beginners: six key questions.Microtubule destabilization is shared by genetic and idiopathic Parkinson's disease patient fibroblasts.Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.Models for LRRK2-Linked Parkinsonism.LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.α-synuclein, LRRK2 and their interplay in Parkinson's disease.The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's diseaseDecoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants.Mitophagy and Parkinson's disease: the PINK1-parkin link.Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?
P2860
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P2860
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The Parkinson's disease associ ...... ompared to autophosphorylation
@ast
The Parkinson's disease associ ...... ompared to autophosphorylation
@en
The Parkinson's disease associ ...... mpared to autophosphorylation.
@nl
type
label
The Parkinson's disease associ ...... ompared to autophosphorylation
@ast
The Parkinson's disease associ ...... ompared to autophosphorylation
@en
The Parkinson's disease associ ...... mpared to autophosphorylation.
@nl
prefLabel
The Parkinson's disease associ ...... ompared to autophosphorylation
@ast
The Parkinson's disease associ ...... ompared to autophosphorylation
@en
The Parkinson's disease associ ...... mpared to autophosphorylation.
@nl
P2093
P2860
P1433
P1476
The Parkinson's disease associ ...... ompared to autophosphorylation
@en
P2093
Alexandra Beilina
Alice Kaganovich
Azad Kumar
Benjamin Wolozin
Diane Chan
Elisa Greggio
P2860
P356
10.1371/JOURNAL.PONE.0008730
P407
P577
2010-01-15T00:00:00Z