Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model - Wikidata - awgldk - TriplyDB

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

http://www.wikidata.org/entity/Q33832846

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Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)Genetically engineered mouse models of Parkinson's disease Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms Subgroup-specific structural variation across 1,000 medulloblastoma genomes Synphilin-1 binds ATP and regulates intracellular energy status A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine Non-motor and motor features in LRRK2 transgenic mice.Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice.Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling CCK Response Deficiency in Synphilin-1 Transgenic Mice.Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice.A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease.Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.New animal models of Parkinson's disease.α-Synuclein in Parkinson's disease.Programmed cell death in Parkinson's disease α-Synuclein and neuronal cell death.Parkinson's disease: from genetics to treatments.Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units Protein Partners of α-Synuclein in Health and Disease.Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila.Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway.Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model.

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Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

http://www.wikidata.org/entity/Q33832846

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Synphilin-1 attenuates neurona ...... nuclein transgenic mouse model

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Synphilin-1 attenuates neurona ...... nuclein transgenic mouse model

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type

label

Synphilin-1 attenuates neurona ...... nuclein transgenic mouse model

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Synphilin-1 attenuates neurona ...... nuclein transgenic mouse model

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prefLabel

Synphilin-1 attenuates neurona ...... nuclein transgenic mouse model

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Synphilin-1 attenuates neurona ...... nuclein transgenic mouse model

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Human Molecular Genetics

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Synphilin-1 attenuates neurona ...... nuclein transgenic mouse model

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David R Borchelt

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Debbie A Swing

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Juan C Troncoso

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Lee J Martin

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Mikhail Pletnikov

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Naoki Masuda

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Timothy H Moran

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Wanli W Smith

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Yideng Liang

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Zhaohui Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

Misfolded proteins partition between two distinct quality control compartments

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

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2087-2098

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10.1093/HMG/DDQ086

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11

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19

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Neal G. Copeland

Nancy A. Jenkins

Christopher A Ross

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2010-02-25T00:00:00Z

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41578260

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20185556

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2865369

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