p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. - Wikidata - awgldk - TriplyDB

p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.

p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.

http://www.wikidata.org/entity/Q34550411

about

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade Phosphoinositides: tiny lipids with giant impact on cell regulation Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Sirt1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction.Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagy in vivo.The two faces of Janus kinases and their respective STATs in mammary gland development and cancer Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice.Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum PI3-kinase mutation linked to insulin and growth factor resistance in vivo Insulin sensitivity: modulation by nutrients and inflammation.Role of phosphoinositide 3-kinase signaling in autoimmunity.Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway?Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats.Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.Phosphoinositide 3-kinase signaling in the vertebrate retina.The PI3K signaling pathway mediates the biological effects of leptin.PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms.Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle.Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice.Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function.PI3K signaling: a crossroads of metabolic regulation The Human Obesity Gene Map: The 2004 Update

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P2860

p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.

http://www.wikidata.org/entity/Q34550411

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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type

label

p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

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MCB.24.1.320-329.2004

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Molecular and Cellular Biology

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p50alpha/p55alpha phosphoinosi ...... enhanced insulin sensitivity.

@en

P2093

Alison Jozsi

http://www.w3.org/2001/XMLSchema#string

Dong Chen

http://www.w3.org/2001/XMLSchema#string

Franck Mauvais-Jarvis

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Laurie J Goodyear

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Matthias Bluher

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Simon J Fisher

http://www.w3.org/2001/XMLSchema#string

P2860

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.

Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.

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320-329

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scholarly article

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10.1128/MCB.24.1.320-329.2004

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