Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
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The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene productsHormone-conditional transformation by fusion proteins of c-Abl and its transforming variantsInduction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.The carboxyl terminus of v-Abl protein can augment SH2 domain function.Two distinct temperature-sensitive alleles at the elav locus of Drosophila are suppressed nonsense mutations of the same tryptophan codon.Modeling Philadelphia chromosome positive leukemias.The extreme carboxyl terminus of v-Abl is required for lymphoid cell transformation by Abelson virus.Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase.bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-ablMultiple steps are required for the induction of tumors by Abelson murine leukemia virus.Carboxyl-terminal determinants of Abelson protein important for lymphoma induction.Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells.Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1.Ras complements the carboxyl terminus of v-Abl protein in lymphoid transformation.A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells.
P2860
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P2860
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
description
1987 nî lūn-bûn
@nan
1987 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@ast
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@en
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@nl
type
label
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@ast
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@en
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@nl
prefLabel
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@ast
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@en
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@nl
P2860
P356
P1476
Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis
@en
P2093
Engelman A
Rosenberg N
P2860
P304
P356
10.1073/PNAS.84.22.8021
P407
P577
1987-11-01T00:00:00Z