Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
about
The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFsPhenotypic Heterogeneity of Monogenic Frontotemporal DementiaMechanisms of granulin deficiency: lessons from cellular and animal modelsPotential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairmentProgranulin: at the interface of neurodegenerative and metabolic diseasesProgranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteinsTargeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiencyMultiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.Progranulin protein levels are differently regulated in plasma and CSF.C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations.TDP-43 in aging and Alzheimer's disease - a reviewLong pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaquesProgranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Progranulin regulates neuronal outgrowth independent of sortilinMisregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor.TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor.Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.Advances in understanding the molecular basis of frontotemporal dementia.Progranulin: an emerging target for FTLD therapies.Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms.Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers.EphA2 is a functional receptor for the growth factor progranulin.Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells.Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration.Mechanisms of toxicity in C9FTLD/ALS.Cellular effects of progranulin in health and disease.Human genetics as a tool to identify progranulin regulators.Structure, function, and mechanism of progranulin; the brain and beyond.Progranulin and TDP-43: mechanistic links and future directions.Frontotemporal dementia: from Mendelian genetics towards genome wide association studies.Progranulin axis and recent developments in frontotemporal lobar degenerationSortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.Frontotemporal lobar degeneration: current knowledge and future challenges.Recent insights into the involvement of progranulin in frontotemporal dementia.Progranulin: a novel regulator of gastrointestinal cancer progression.Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.
P2860
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P2860
Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Genome-wide screen identifies ...... anulin levels in human plasma.
@ast
Genome-wide screen identifies ...... anulin levels in human plasma.
@en
Genome-wide screen identifies ...... anulin levels in human plasma.
@nl
type
label
Genome-wide screen identifies ...... anulin levels in human plasma.
@ast
Genome-wide screen identifies ...... anulin levels in human plasma.
@en
Genome-wide screen identifies ...... anulin levels in human plasma.
@nl
prefLabel
Genome-wide screen identifies ...... anulin levels in human plasma.
@ast
Genome-wide screen identifies ...... anulin levels in human plasma.
@en
Genome-wide screen identifies ...... anulin levels in human plasma.
@nl
P2093
P2860
P50
P1476
Genome-wide screen identifies ...... anulin levels in human plasma.
@en
P2093
Alexandra M Nicholson
Dena Hernandez
Gina D Bisceglio
Ian R Mackenzie
J Raphael Gibbs
Julia E Crook
Matt Baker
Minerva M Carrasquillo
Neill R Graff-Radford
NiCole Finch
P2860
P304
P356
10.1016/J.AJHG.2010.11.002
P407
P50
P577
2010-11-18T00:00:00Z