Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons
about
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channelsSodium channel selectivity filter regulates antiarrhythmic drug bindingUse-dependent inhibition of Na+ currents by benzocaine homologs.QX-314 restores gating charge immobilization abolished by chloramine-T treatment in squid giant axons.Characterization of cocaine-induced block of cardiac sodium channels.Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaineIsoform-specific lidocaine block of sodium channels explained by differences in gatingState-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit.A quantitative description of QX222 blockade of sodium channels in squid axons.Removal of sodium inactivation and block of sodium channels by chloramine-T in crayfish and squid giant axonsAnoxic and ischemic injury of myelinated axons in CNS white matter: from mechanistic concepts to therapeutics.Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers.Cardiotoxic effects of fenfluramine hydrochloride on isolated cardiac preparations and ventricular myocytes of guinea-pigs.Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation.Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analoguesMethadone block of K+ current in squid giant fiber lobe neuronsThe position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channelsBlock of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence.Molecular and structural basis of resting and use-dependent block of sodium current defined using disopyramide analogues.Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2',6'-xylide, a neutral lidocaine homologue.Open-channel block by internally applied amines inhibits activation gate closure in batrachotoxin-activated sodium channels.The activation gate of the sodium channel controls blockade and deblockade by disopyramide in rabbit Purkinje fibres.Compound-specific Na+ channel pore conformational changes induced by local anaesthetics.Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue.Sense and Insensibility - An Appraisal of the Effects of Clinical Anesthetics on Gastropod and Cephalopod Molluscs as a Step to Improved Welfare of Cephalopods
P2860
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P2860
Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons
description
1985 nî lūn-bûn
@nan
1985 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
Na channel activation gate mod ...... esthetics in squid giant axons
@ast
Na channel activation gate mod ...... esthetics in squid giant axons
@en
Na channel activation gate mod ...... esthetics in squid giant axons
@nl
type
label
Na channel activation gate mod ...... esthetics in squid giant axons
@ast
Na channel activation gate mod ...... esthetics in squid giant axons
@en
Na channel activation gate mod ...... esthetics in squid giant axons
@nl
prefLabel
Na channel activation gate mod ...... esthetics in squid giant axons
@ast
Na channel activation gate mod ...... esthetics in squid giant axons
@en
Na channel activation gate mod ...... esthetics in squid giant axons
@nl
P2860
P1433
P1476
Na channel activation gate mod ...... esthetics in squid giant axons
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(85)83965-5
P407
P577
1985-05-01T00:00:00Z