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Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITORNovel isoquinolone PDK1 inhibitors discovered through fragment-based lead discoveryNutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeastGene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like PhenotypePhosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion.Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formationTargeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screeningA novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target.Physiological regulation of Akt activity and stability.Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growthAdvanced treatment for basal cell carcinomas.Small-molecule inhibitors of the PI3K signaling networkPDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer.Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal moleculesSensitive multiplexed analysis of kinase activities and activity-based kinase identification.Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network.Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease ModelsTargeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia.An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes.Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytesActivated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein.Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65.3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway.Striking the balance between PTEN and PDK1: it all depends on the cell context.Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy.PDK1 inhibitorsAcute regulation of PDK1 by a complex interplay of molecular switches.PDK1 disruptors and modulators: a patent review.Inhibition of cell survival and proliferation by nimbolide in human androgen-independent prostate cancer (PC-3) cells: involvement of the PI3K/Akt pathway.Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Small-molecule inhibitors of PDK1.
@ast
Small-molecule inhibitors of PDK1.
@en
Small-molecule inhibitors of PDK1.
@nl
type
label
Small-molecule inhibitors of PDK1.
@ast
Small-molecule inhibitors of PDK1.
@en
Small-molecule inhibitors of PDK1.
@nl
prefLabel
Small-molecule inhibitors of PDK1.
@ast
Small-molecule inhibitors of PDK1.
@en
Small-molecule inhibitors of PDK1.
@nl
P356
P1433
P1476
Small-molecule inhibitors of PDK1.
@en
P2093
Christian Peifer
P2860
P304
P356
10.1002/CMDC.200800195
P577
2008-12-01T00:00:00Z