The permeation pathway of neurotransmitter-gated ion channels.
about
An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kineticsCrystal structure of the CorA Mg2+ transporterComputer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolutionThe emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor.Structure and dynamics of the pore-lining helix of the nicotinic receptor: MD simulations in water, lipid bilayers, and transbilayer bundles.Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801.Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors.Cocaine: mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique.A distinct contribution of the delta subunit to acetylcholine receptor channel activation revealed by mutations of the M2 segmentCation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila.A model of the closed form of the nicotinic acetylcholine receptor m2 channel pore.Electrostatic interactions between the syntaxin membrane anchor and neurotransmitter passing through the fusion pore.Homology model of the GABAA receptor examined using Brownian dynamicsMinimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.Probing ion-channel pores one proton at a time.EXP-1 is an excitatory GABA-gated cation channel.A model of the glycine receptor deduced from Brownian dynamics studies.Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans.Voltage-jump relaxation kinetics for wild-type and chimeric beta subunits of neuronal nicotinic receptorsTris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 regionIdentification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channelsCation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity.Site-specific, photochemical proteolysis applied to ion channels in vivo.In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor.Stoichiometric pore mutations of the GABAAR reveal a pattern of hydrogen bonding with picrotoxin.Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.The structural basis of function in Cys-loop receptors.Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics.Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method.Electrostatics and the ion selectivity of ligand-gated channels.Defining the transmembrane helix of M2 protein from influenza A by molecular dynamics simulations in a lipid bilayer.Chloride channels of glycine and GABA receptors with blockers: Monte Carlo minimization and structure-activity relationships.Pores formed by the nicotinic receptor m2delta Peptide: a molecular dynamics simulation study.Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions.Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor.New views of multi-ion channels.Assigning functions to residues in the acetylcholine receptor channel region (review).Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor.
P2860
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P2860
The permeation pathway of neurotransmitter-gated ion channels.
description
1992 nî lūn-bûn
@nan
1992 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
The permeation pathway of neurotransmitter-gated ion channels.
@ast
The permeation pathway of neurotransmitter-gated ion channels.
@en
type
label
The permeation pathway of neurotransmitter-gated ion channels.
@ast
The permeation pathway of neurotransmitter-gated ion channels.
@en
prefLabel
The permeation pathway of neurotransmitter-gated ion channels.
@ast
The permeation pathway of neurotransmitter-gated ion channels.
@en
P1476
The permeation pathway of neurotransmitter-gated ion channels.
@en
P2093
P304
P356
10.1146/ANNUREV.BB.21.060192.001411
P577
1992-01-01T00:00:00Z