Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.
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General anaesthetic actions on ligand-gated ion channelsStructural mechanisms underlying benzodiazepine modulation of the GABA(A) receptorChannel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segmentStructural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptorCrystal structure of a human GABAA receptorAllosteric activation mechanism of the cys-loop receptorsMapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete modelTwo gamma2L subunit domains confer low Zn2+ sensitivity to ternary GABA(A) receptorsMicroscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic functionPoint mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gatingGlycine receptor mouse mutants: model systems for human hyperekplexiaLength and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitizationA single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels.Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels.Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.Movement of gating machinery during the activation of rod cyclic nucleotide-gated channels.Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila.Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptorsM2 pore mutations convert the glycine receptor channel from being anion- to cation-selective.NMR structures of the second transmembrane domain of the human glycine receptor alpha(1) subunit: model of pore architecture and channel gating.Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity.Homology model of the GABAA receptor examined using Brownian dynamicsA transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods.EXP-1 is an excitatory GABA-gated cation channel.Disulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines.Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.A pentasymmetric open channel blocker for Cys-loop receptor channels.5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals.Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function.Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.A CLAG3 mutation in an amphipathic transmembrane domain alters malaria parasite nutrient channels and confers leupeptin resistance.The TM2 6' position of GABA(A) receptors mediates alcohol inhibitionGABAC receptor ion channels.Charge selectivity of the Cys-loop family of ligand-gated ion channels.A channel in a transporter.Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain
P2860
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P2860
Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Identification of channel-lini ...... BA(A) receptor alpha1 subunit.
@ast
Identification of channel-lini ...... BA(A) receptor alpha1 subunit.
@en
type
label
Identification of channel-lini ...... BA(A) receptor alpha1 subunit.
@ast
Identification of channel-lini ...... BA(A) receptor alpha1 subunit.
@en
prefLabel
Identification of channel-lini ...... BA(A) receptor alpha1 subunit.
@ast
Identification of channel-lini ...... BA(A) receptor alpha1 subunit.
@en
P2860
P356
P1476
Identification of channel-lini ...... BA(A) receptor alpha1 subunit.
@en
P2860
P304
P356
10.1085/JGP.107.2.195
P577
1996-02-01T00:00:00Z