Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
about
Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiaThe AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLFmSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factorThe LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cellsSpecific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemiaHelix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cellsRegulation of pT alpha gene expression by a dosage of E2A, HEB, and SCLGradient of E2A activity in B-cell development.Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cellsTranscriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALLTarget-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoproteinRFP represses transcriptional activation by bHLH transcription factorsThe DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in miceThe TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursorsDecoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1The E47 transcription factor binds to the enhancer sequences of recombinant murine leukemia viruses and influences enhancer functionAn scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cellsChromatin immunoselection defines a TAL-1 target geneDisruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient miceEnhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic miceEpstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development.N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsEctopic expression of E47 or E12 promotes the death of E2A-deficient lymphomasThe t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 geneTranscriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells.Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells.Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletionTal1/SCL binding to pericentromeric DNA represses transcription.A new allele of Lyl1 confirms its important role in hematopoietic stem cell function.The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis.Unanticipated repression function linked to erythroid Krüppel-like factor.ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.Helix-loop-helix transcription factors mediate activation and repression of the p75LNGFR geneE2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells.
P2860
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P2860
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
@ast
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
@en
type
label
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
@ast
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
@en
prefLabel
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
@ast
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
@en
P2093
P2860
P356
P1476
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.13.5947
P407
P577
1994-06-01T00:00:00Z