Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.
about
The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conservedThe fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesDNA polymerase delta in DNA replication and genome maintenanceHydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacityA strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coliMutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesisDNA polymerases at the eukaryotic fork-20 years laterA Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA StrandsDivision of labor at the eukaryotic replication forkDNA replication error-induced extinction of diploid yeastDominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathwayRibonucleotides are signals for mismatch repair of leading-strand replication errorsNormally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantA cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae.Genome-wide model for the normal eukaryotic DNA replication fork.The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNAActive site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.Kinetic analysis of the unique error signature of human DNA polymerase ν.Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae.Balancing eukaryotic replication asymmetry with replication fidelity.The lower bound to the evolution of mutation rates.Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelityRegulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction.Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter.Mutator alleles of yeast DNA polymerase zeta.Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.Too many mutants with multiple mutations.DNA polymerase epsilon: a polymerase of unusual size (and complexity).Dividing the workload at a eukaryotic replication fork.Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta.Steric gate variants of UmuC confer UV hypersensitivity on Escherichia coli.High fidelity and lesion bypass capability of human DNA polymerase deltaPCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.
P2860
Q21144935-0215196A-B3D8-455C-9EF7-79EB4C61CC6AQ24630867-4E4F6F7E-03D6-4FC0-BA0E-925E23920516Q26991961-363ACD8C-C312-417F-B145-C6F78A2CBB7DQ27644639-01D1D4B6-0144-43F1-8B60-C0EBEFFD9D76Q27650688-0F4C360C-AA6E-47B6-B8A2-84CAEBB6060EQ27677020-23F64302-07D2-469B-BF88-E32F88CE26A4Q28245001-CFBFA625-ECE4-44DB-97DA-8780B5CAE2AAQ28255094-75126073-2005-46AA-8190-7B5F19C66F52Q28264543-4E700B19-C125-4A2B-A865-9FCDD563EA04Q28277921-54E4EAB0-E391-4A72-90E4-DFDA2B42F47CQ28305177-2AD2F22C-820A-46DA-B66A-C465B4C25C74Q28534756-7939D0D4-7816-4356-A4A3-AE3C3B50E1AFQ28689053-2D2DFCC9-992A-41BF-8615-74976FE1C9E6Q33572538-139007BA-C9EA-4DB8-A7C8-8D516FFCE6C2Q33591410-4EED2102-6930-4186-8BEA-E1FB0CD81FFBQ33628462-2A178C3F-41B8-4A54-BB44-DBEDD8213E57Q33704744-AF4968FA-7566-4EF9-920E-CF1B46B712D5Q33814597-A76313BF-4815-4184-8FAB-19A20C036BCCQ33997247-BD5F5731-C728-4B19-A0EC-7E27E2BDBCD0Q34186488-3C1FD611-06A3-4EBE-A4D7-A871E0DA96FFQ34225193-383EE58B-62BD-4B0D-99E6-0CB29E727B5DQ35152167-71868432-454A-4ADB-9CE6-3777A5F33208Q35165645-B87CBFCF-40F0-43C8-9D80-D1B01159673BQ35291466-338E02B4-3474-430D-8531-E848C88541B1Q35362334-101AD213-1834-4CC9-8E22-3CA0BCA08F9AQ35562130-DD709538-6F5E-41BB-8203-EE872F850A0BQ35616094-9A6E32DE-6183-4CF3-A649-14CD90A77E53Q35837411-62B97E14-C725-4B7E-82EE-E52EA1E19070Q35903810-63BDAC47-9315-448E-9A75-D28CA278CAA7Q36228037-4ED2C9D9-D0DA-4C71-83F5-58BC05FA8EA3Q36247787-E634265A-78EB-423F-A0A1-60CBC6AD432DQ36338245-7AA1349D-9F7D-489B-9C09-6E3976D47EE1Q36491712-41AE8792-5253-4EF2-8CDE-DFD0A40578EFQ36961060-0C90137D-65E1-43EA-95B8-49C25B4DC5D5Q37149735-7C2FB7C0-AC35-44F1-A5CC-F93BE57B08B9Q37235387-9F2A827D-0B0E-40A2-97A3-047428F89AADQ37274991-5732FD21-E9EF-4F16-926D-DDF776387A62Q37414576-9F0FF84B-F511-4734-8069-1AFDCB4E62C2Q37482417-9DB61380-D767-499A-9E37-B4E312619DEBQ37483304-D1CC3334-2CDA-46B7-9FF0-D3FF94FC2310
P2860
Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Inefficient proofreading and b ...... revisiae DNA polymerase delta.
@ast
Inefficient proofreading and b ...... revisiae DNA polymerase delta.
@en
type
label
Inefficient proofreading and b ...... revisiae DNA polymerase delta.
@ast
Inefficient proofreading and b ...... revisiae DNA polymerase delta.
@en
prefLabel
Inefficient proofreading and b ...... revisiae DNA polymerase delta.
@ast
Inefficient proofreading and b ...... revisiae DNA polymerase delta.
@en
P2093
P2860
P356
P1476
Inefficient proofreading and b ...... erevisiae DNA polymerase delta
@en
P2093
Carrie M Stith
Peter M J Burgers
Stephanie A Nick McElhinny
P2860
P304
P356
10.1074/JBC.M609591200
P407
P577
2006-11-22T00:00:00Z