Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. - Wikidata - awgldk - TriplyDB

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

http://www.wikidata.org/entity/Q35992079

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AID/APOBEC cytosine deaminase induces genome-wide kataegis Mutational heterogeneity in cancer and the search for new cancer-associated genes Managing Single-Stranded DNA during Replication Stress in Fission Yeast Breaking bad: The mutagenic effect of DNA repair The FHIT gene product: tumor suppressor and genome "caretaker"Do mutator mutations fuel tumorigenesis?The APOBEC3 family of retroelement restriction factors Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity Migrating bubble during break-induced replication drives conservative DNA synthesis.Mutational signatures associated with tobacco smoking in human cancer APOBEC3 Interference during Replication of Viral Genomes AID/APOBEC deaminases and cancer Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer Hypermutation in human cancer genomes: footprints and mechanisms APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication Comprehensive molecular characterization of urothelial bladder carcinoma Initiation of genome instability and preneoplastic processes through loss of Fhit expression Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent Guanine holes are prominent targets for mutation in cancer and inherited disease Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer Nanoscale structure and dynamics of ABOBEC3G complexes with single-stranded DNA.Ancient genes establish stress-induced mutation as a hallmark of cancer Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions.The dark side of DNA repair Is homologous recombination really an error-free process?Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair.Medicine. Combating evolution to fight disease.Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness Error-prone polymerase activity causes multinucleotide mutations in humans.The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1.DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency Evidence for APOBEC3B mutagenesis in multiple human cancers

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Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

http://www.wikidata.org/entity/Q35992079

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Deepak Mav

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Joan Sterling

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Leszek J Klimczak

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Ruchir Shah

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Shawn Harris

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P2860

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

The genomic complexity of primary human prostate cancer

Initial genome sequencing and analysis of multiple myeloma

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

Base excision repair intermediates are mutagenic in mammalian cells

Increased mutagenesis and unique mutation signature associated with mitotic gene conversion

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.

Retroviral restriction by APOBEC proteins

Cytidine deamination of retroviral DNA by diverse APOBEC proteins

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

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