Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice - Wikidata - awgldk - TriplyDB

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

http://www.wikidata.org/entity/Q36044979

about

Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP)Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination Defective DNA repair and increased genomic instability in Artemis-deficient murine cells Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20 Harnessing a high cargo-capacity transposon for genetic applications in vertebrates Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systems Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.Increased γ-H2A.X intensity in response to chronic medium-dose-rate γ-ray irradiation XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.The juvenile alopecia mutation (jal) maps to mouse Chromosome 2, and is an allele of GATA binding protein 3 (Gata3).Formation of coding joints in V(D)J recombination-inducible severe combined immune deficient pre-B cell lines.Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle.Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2-/- IL-2Rγ-/- mice: a promising model for studying human disease.Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.Host-derived pericytes and Sca-1+ cells predominate in the MART-1- stroma fraction of experimentally induced melanoma.The role of the non-homologous end-joining pathway in lymphocyte development.A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency.The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest.Use of humanized severe combined immunodeficient mice for human vaccine development.A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation.Molecular biology of atherosclerosis.The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity.DNA-PK activity is associated with caspase-dependent myogenic differentiation.Cell death and thymic tolerance.UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells.DNA-PK is essential only for coding joint formation in V(D)J recombination DNA-dependent protein kinase-independent activation of p53 in response to DNA damage.

P2860

Q24339466-5B7DACD8-8878-4805-A64E-5F34EC5B2696 Q27919628-C51B45F2-91EE-43D2-A679-B4CD15A0286C Q28070584-807AFA2F-3909-4909-86C9-5DB37CE88315 Q28145155-73D195EE-3CCA-4A80-801D-B7C600E82822 Q28145271-F759EED6-17E5-45F6-8315-B35678C0D839 Q28472958-C4BDBC18-ADCB-406D-8A88-F745C1A1DAC1 Q28508673-C99E123A-2E83-40E9-91F9-B182262CD891 Q28513655-462A9B6D-504E-4F9F-88E9-63D1CE0F9A05 Q28608946-4BB854F6-103D-44E6-BCC8-DA5EFA1CF42B Q32082716-D1AED250-13D2-448C-9E44-6AE8809C93CD Q33263256-20436D0C-10D4-451A-B662-0A6890A71ED8 Q33589392-C779D69F-6424-4D46-A8CF-F275A5AC25A2 Q33597709-475E71D7-0781-413D-B40D-A11A8CF55BA4 Q33958394-920F7A59-CBA4-4C56-9159-308DB33EE5BD Q33963869-6B2F6F6B-0D4D-4104-A625-DDA75371B426 Q33965750-1F1D0373-C097-4FD8-9A74-70F69301FD14 Q33966818-09119C56-AFDA-4823-9807-56BFF6DA223F Q33968202-A8F6601F-92CC-4B30-8660-3611C9EB0A89 Q34145974-7F5FD778-1F99-4447-A85A-A467C138A63A Q34428739-64C4A504-5005-4133-B768-7B734C84A7C8 Q34669732-3C8BE383-3A4E-45D5-82E1-BCEF40D00001 Q34713739-B8F17FB7-78E7-44E9-BA98-709741C7C4D6 Q34798187-603DEF46-0592-40E4-A846-EDC8D772082F Q34992049-DCB8E5E5-9C3C-4F25-A6E6-7D34C41D4656 Q35054512-6B2FCB20-717D-41AB-B07F-0408B5BD75C8 Q35201052-01150503-D257-4B76-B30B-A5BA9A39EDD9 Q35637089-74A24D2A-5EBC-4EA3-A45C-1D117F8B8777 Q35767922-46556762-AF10-42CF-BAF2-45078C80B2A7 Q35830410-D2017867-FCB3-4A4A-8FA5-1544A931680D Q36404053-00DBA71D-F10A-4FD6-BE13-64C87B3639C7 Q37109768-6C3814F5-1607-4D71-A471-279705065EE2 Q37354186-7CBF98DE-6B27-4D8F-A033-1D56543CA719 Q37413665-C87B21B0-4A69-4183-97DD-A7AAD0F6F809 Q38125279-760F0965-A95B-4025-876C-D8BEBE257ABC Q38314660-1A89A0A1-12A8-44DD-A599-B86F10E6BA10 Q38752459-380308DC-694B-4FCD-8A96-7257937DD079 Q39277510-2961175B-26A7-4413-8E0D-16C200718FD1 Q39723274-E910BFB3-E74F-4F52-8A97-57596A46A966 Q39724861-4A01A8E8-646C-4C41-AC73-5AE4243313E9 Q40950612-EF26103E-0C02-4048-A856-DA345A3AC064

P2860

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

http://www.wikidata.org/entity/Q36044979

description

1997 nî lūn-bûn

@nan

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

1997年论文

@zh

1997年论文

@zh-cn

name

Nonsense mutation at Tyr-4046 ...... ombined immune deficiency mice

@ast

Nonsense mutation at Tyr-4046 ...... ombined immune deficiency mice

@en

type

label

Nonsense mutation at Tyr-4046 ...... ombined immune deficiency mice

@ast

Nonsense mutation at Tyr-4046 ...... ombined immune deficiency mice

@en

prefLabel

Nonsense mutation at Tyr-4046 ...... ombined immune deficiency mice

@ast

Nonsense mutation at Tyr-4046 ...... ombined immune deficiency mice

@en

P1433

Q36044979-A9160529-78D0-4362-9AA8-99FC88D98F74

P1476

Q36044979-34B8D853-AB65-44B0-876A-A19EC436B9E1

P2093

Q36044979-04C077A1-A75C-4BDB-8FAE-C6AD809AEC38

Q36044979-26FC8071-BADD-4C14-A621-CD046C4A856E

Q36044979-30A7A62D-320A-4340-877E-34E2014EECC9

Q36044979-3FBEB992-11E9-4DE8-A830-00E1CB74F7BD

Q36044979-47B32CA6-4886-48FC-835E-3550C1FA6733

Q36044979-55A00B79-8A55-45A6-99D7-7160C949EB6B

Q36044979-5B649BE4-90D2-426F-9BBA-9A177048AC04

Q36044979-67A2EE49-5333-41F3-B437-D4B82D10E8CC

Q36044979-848F4F2E-0F87-440E-A7BC-64F56BF200C1

Q36044979-ACD8CCB7-222F-4897-BB94-4F327655BAED

P2860

Q36044979-08A91DAC-6F1F-48D0-9761-3E3FBCBDC799

Q36044979-1294B309-0AC1-4E94-823A-E345D0826A55

Q36044979-14BE4EAB-4A36-494B-8966-BBE85E90BE70

Q36044979-228F181A-B6FA-4AC1-84F7-8E36A275F40D

Q36044979-36733D0D-0E39-419A-B485-B3925DCE2755

Q36044979-39A93F7E-88F1-4950-8EB5-EB6DB415874C

Q36044979-3ACF57F8-E31A-4CCE-ADC4-B9275E46C5A6

Q36044979-4DFA4D03-91DA-4413-93F4-099E5944D7FC

Q36044979-4E3F32CE-20EA-465F-8497-020737459DB1

Q36044979-529D92CE-5570-424E-B681-58A3844924C3

P304

Q36044979-CCA3951B-DF36-4C2A-AAF8-A8E39F753FD0

P31

Q36044979-70ED4FE3-6F4A-4C33-86C8-1502F103390D

P356

Q36044979-D009BD70-04E4-4064-8605-37BCADA3F518

P407

Q36044979-D0E1345A-4B6A-4ED1-A420-F21F63CE3F14

P433

Q36044979-F6F023D5-94CE-4E2E-9654-E350A5DB60C3

P478

Q36044979-79B555AD-A73F-41B6-9557-5321E0E4131B

P577

Q36044979-AE8A6641-A74E-4201-9FDE-50B49AAA0805

P5875

Q36044979-442C54E3-271B-4EA2-9116-286CF4090273

P698

Q36044979-9FB03059-76B2-45CC-94F1-FEF75D847700

P932

Q36044979-0576C4B6-59F4-4813-A6F1-1BA48186D026

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Nonsense mutation at Tyr-4046 ...... ombined immune deficiency mice

@en

P2093

A Fujimori

http://www.w3.org/2001/XMLSchema#string

K Hamatani

http://www.w3.org/2001/XMLSchema#string

K Mita

http://www.w3.org/2001/XMLSchema#string

K Tatsumi

http://www.w3.org/2001/XMLSchema#string

M Abe

http://www.w3.org/2001/XMLSchema#string

M Itoh

http://www.w3.org/2001/XMLSchema#string

M Mori

http://www.w3.org/2001/XMLSchema#string

M Morimyo

http://www.w3.org/2001/XMLSchema#string

M Muto

http://www.w3.org/2001/XMLSchema#string

R Araki

http://www.w3.org/2001/XMLSchema#string

P2860

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer

Screening lambdagt recombinant clones by hybridization to single plaques in situ

A severe combined immunodeficiency mutation in the mouse

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

Real time quantitative PCR

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells

P304

2438-2443

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.94.6.2438

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

94

http://www.w3.org/2001/XMLSchema#string

P577

1997-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

14096539

http://www.w3.org/2001/XMLSchema#string

P698

9122213

http://www.w3.org/2001/XMLSchema#string

P932

20106

http://www.w3.org/2001/XMLSchema#string