Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
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Protein phosphatases and Alzheimer's diseaseSynapses and Alzheimer's diseaseCalcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survivalElevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.Development of a Fluorescent Quenching Based High Throughput Assay to Screen for Calcineurin InhibitorsLoss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status.Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityDysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease.Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice.Selective induction of calcineurin activity and signaling by oligomeric amyloid betaProteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.Insulin resistance in Alzheimer's disease.Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibitionA translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.Herbal formula GAPT prevents beta amyloid deposition induced Ca(2+)/Calmodulin-dependent protein kinase II and Ca(2+)/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice.Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant.Hippocampal Injections of Oligomeric Amyloid β-peptide (1-42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway.Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophreniaInterleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity.Normal cognition in transgenic BRI2-Aβ mice.Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats.Reduced Incidence of Dementia in Solid Organ Transplant Patients Treated with Calcineurin InhibitorsTau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signalingIntermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition.Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice.Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging.Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology.PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancementProtein profiles associated with context fear conditioning and their modulation by memantine.Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease.Alzheimer's disease: synapses gone cold.
P2860
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P2860
Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Acute inhibition of calcineuri ...... in Tg2576 APP transgenic mice
@ast
Acute inhibition of calcineuri ...... in Tg2576 APP transgenic mice
@en
type
label
Acute inhibition of calcineuri ...... in Tg2576 APP transgenic mice
@ast
Acute inhibition of calcineuri ...... in Tg2576 APP transgenic mice
@en
prefLabel
Acute inhibition of calcineuri ...... in Tg2576 APP transgenic mice
@ast
Acute inhibition of calcineuri ...... in Tg2576 APP transgenic mice
@en
P2093
P2860
P1476
Acute inhibition of calcineuri ...... in Tg2576 APP transgenic mice
@en
P2093
Dale Hogan
Giulio Taglialatela
Kelly T Dineley
Wen-Ru Zhang
P2860
P304
P356
10.1016/J.NLM.2007.03.010
P577
2007-05-22T00:00:00Z