Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification. - Wikidata - awgldk - TriplyDB

Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.

Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.

http://www.wikidata.org/entity/Q36371091

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Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities.Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis Clinical laboratory analysis of immunoglobulin heavy chain variable region genes for chronic lymphocytic leukemia prognosis.Immunologic aspects of monoclonal B-cell lymphocytosis Lymphoid malignancies: the dark side of B-cell differentiation.AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing Complex regulation and function of activation-induced cytidine deaminase.Intraclonal cell expansion and selection driven by B cell receptor in chronic lymphocytic leukemia.Somatic hypermutation patterns in germinal center B cell malignancies.Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukemia.Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia.IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient process Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA.Human memory B cells.Immunoglobulin gene repertoire diversification and selection in the stomach - from gastritis to gastric lymphomas.Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma.Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin.AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation.A novel human B cell subpopulation representing the initial germinal center population to express AID.Mutational status of IgV(H) genes in B-cell chronic lymphocytic leukemia and prognosis: percent mutations or antigen-driven selection?The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia.Analysis of IgV gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery.Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a V(H)-gene is unmutated?Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis.Next-generation IgVH sequencing CLL-like monoclonal B-cell lymphocytosis reveals frequent oligoclonality and ongoing hypermutation.IgV gene intraclonal diversification and clonal evolution in B-cell chronic lymphocytic leukaemia.Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia

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Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.

http://www.wikidata.org/entity/Q36371091

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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Chronic lymphocytic leukemia B ...... (H)DJ(H) gene diversification.

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Chronic lymphocytic leukemia B ...... (H)DJ(H) gene diversification.

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Chronic lymphocytic leukemia B ...... (H)DJ(H) gene diversification.

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Chronic lymphocytic leukemia B ...... (H)DJ(H) gene diversification.

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Chronic lymphocytic leukemia B ...... (H)DJ(H) gene diversification.

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Chronic lymphocytic leukemia B ...... (H)DJ(H) gene diversification.

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Journal of Experimental Medicine

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Chronic lymphocytic leukemia B ...... V(H)DJ(H) gene diversification

@en

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Carmela Gurrieri

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Emilia Albesiano

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Hong Zan

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Kanti R Rai

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Nicholas Chiorazzi

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Paolo Casali

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Peter McGuire

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Vincent Vinciguerra

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Xiao-Jie Yan

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P2860

Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas

BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

Germinal centers

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

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629-639

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scholarly article

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10.1084/JEM.20011693

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5

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196

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Manlio Ferrarini

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2002-09-01T00:00:00Z

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236242987

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12208878

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2194006

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