TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways. - Wikidata - awgldk - TriplyDB

TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

http://www.wikidata.org/entity/Q36247028

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Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes Frontotemporal Lobar Degeneration and MicroRNAs Mechanisms of granulin deficiency: lessons from cellular and animal models Potential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairment Chronic Traumatic Encephalopathy in Athletes Involved with High-impact Sports Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data Alteration of the microRNA network during the progression of Alzheimer's disease.Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study.TMEM106B expression is reduced in Alzheimer's disease brains RNA metabolism in neurodegenerative disease.Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).The emerging roles of microRNAs in the pathogenesis of frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum disorders PLD3 is accumulated on neuritic plaques in Alzheimer's disease brains.Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.The TMEM106B locus and TDP-43 pathology in older persons without FTLD Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.A novel Alzheimer disease locus located near the gene encoding tau protein.Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Functional microRNAs in Alzheimer's disease and cancer: differential regulation of common mechanisms and pathways.A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls.TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers.Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis.Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank.Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity.Microarray gene and miRNA expression studies: looking for new therapeutic targets for frontotemporal lobar degeneration.Frontotemporal Lobar Degeneration: Mechanisms and Therapeutic Strategies.

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TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

http://www.wikidata.org/entity/Q36247028

description

2012 nî lūn-bûn

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2012年論文

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2012年论文

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2012年论文

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name

TMEM106B, the risk gene for fr ...... affects progranulin pathways.

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TMEM106B, the risk gene for fr ...... affects progranulin pathways.

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type

label

TMEM106B, the risk gene for fr ...... affects progranulin pathways.

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TMEM106B, the risk gene for fr ...... affects progranulin pathways.

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prefLabel

TMEM106B, the risk gene for fr ...... affects progranulin pathways.

@ast

TMEM106B, the risk gene for fr ...... affects progranulin pathways.

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JNEUROSCI.0521-12.2012

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Journal of Neuroscience

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TMEM106B, the risk gene for fr ...... affects progranulin pathways.

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Alice S Chen-Plotkin

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Emily Bill

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Johanna I Busch

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Laura Volpicelli-Daley

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Linda K Kwong

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Michael D Gallagher

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Sebastian Akle

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Travis L Unger

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Virginia M-Y Lee

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Vivianna Van Deerlin

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A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis.

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP

miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis

Prediction of mammalian microRNA targets

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Striatal microRNA controls cocaine intake through CREB signalling

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11213-11227

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10.1523/JNEUROSCI.0521-12.2012

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33

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32

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John Q. Trojanowski

Murray Grossman

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2012-08-01T00:00:00Z

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22895706

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3446826

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