ATR signaling can drive cells into senescence in the absence of DNA breaks.
about
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsCommon mechanisms of PIKK regulationLinking replication stress with heterochromatin formationChromatin perturbations during the DNA damage response in higher eukaryotesChemical strategies for development of ATR inhibitorsActivation of the ATR kinase by the RPA-binding protein ETAA1ETAA1 acts at stalled replication forks to maintain genome integrityATR: an essential regulator of genome integrityA p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrityH2AX is required for cell cycle arrest via the p53/p21 pathwayPersistent telomere damage induces bypass of mitosis and tetraploidy.Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stressRetinoblastoma loss modulates DNA damage response favoring tumor progressionAkt/PKB suppresses DNA damage processing and checkpoint activation in late G2.Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.Tumor suppression by p53: making cells senescent.Aging, cellular senescence, and cancerAkt: a double-edged sword in cell proliferation and genome stability.Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivoInterferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activityUnfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastomap53 governs telomere regulation feedback too, via TRF2.TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes.Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence.Modelling the onset of senescence at the G1/S cell cycle checkpoint.High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.Molecular damage in cancer: an argument for mTOR-driven agingTOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality.Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stabilityThe emerging role of nuclear architecture in DNA repair and genome maintenance.The ATR barrier to replication-born DNA damage.An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells.
P2860
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P2860
ATR signaling can drive cells into senescence in the absence of DNA breaks.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
ATR signaling can drive cells into senescence in the absence of DNA breaks.
@ast
ATR signaling can drive cells into senescence in the absence of DNA breaks.
@en
type
label
ATR signaling can drive cells into senescence in the absence of DNA breaks.
@ast
ATR signaling can drive cells into senescence in the absence of DNA breaks.
@en
prefLabel
ATR signaling can drive cells into senescence in the absence of DNA breaks.
@ast
ATR signaling can drive cells into senescence in the absence of DNA breaks.
@en
P2093
P2860
P356
P1433
P1476
ATR signaling can drive cells into senescence in the absence of DNA breaks.
@en
P2093
Luis I Toledo
Matilde Murga
Oscar Fernandez-Capetillo
Paula Gutierrez-Martinez
Rebeca Soria
P2860
P304
P356
10.1101/GAD.452308
P577
2008-02-01T00:00:00Z