A novel family of variable region genes of the human immunoglobulin heavy chain.
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Dispersed localization of D segments in the human immunoglobulin heavy-chain locusOrganization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segmentsPhysical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elementsThe complete nucleotide sequence of the human immunoglobulin heavy chain variable region locusClonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synoviumA deletion map of the human immunoglobulin heavy chain variable regionConservation of sequence in recombination signal sequence spacersConservation of an immunoglobulin variable-region gene family indicates a specific, noncoding functionHuman rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: auto- and multi-reactivity, diverse VH gene segment usage and preferential usage of V lambda IIIb.Nucleotide sequences and three-dimensional modelling of the VH and VL domains of two human monoclonal antibodies specific for the D antigen of the human Rh-blood-group system.Sequence analysis of monoclonal antibodies derived from a patient with idiopathic thrombocytopenic purpura.Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotypeDetermination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa.Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire.The physical organization of the human immunoglobulin heavy chain gene complex.Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable regionMolecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseasesMolecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypesComplete physical map of the human immunoglobulin heavy chain constant region gene complex.Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotypeHAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VH locus.Nonuniform linkage disequilibrium within a 1,500-kb region of the human immunoglobulin heavy-chain complexMolecular approaches to the study of human B-cell and (auto)antibody repertoire generation and selection.Specificity and idiotope expression of IgM produced by CD5+ and CD5- cord blood B-cell clones.Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles.Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.Predicting amino acid sequences of the antibody human VH chains from its first several residues.The human VH repertoire: a restricted set of VH genes may be the target of immune regulation.Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosusComplete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient.Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidaseClonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutationDistinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity.Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.Clonal diversity in the B cell repertoire of patients with X-linked agammaglobulinemia.Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene.
P2860
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P2860
A novel family of variable region genes of the human immunoglobulin heavy chain.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
A novel family of variable region genes of the human immunoglobulin heavy chain.
@ast
A novel family of variable region genes of the human immunoglobulin heavy chain.
@en
type
label
A novel family of variable region genes of the human immunoglobulin heavy chain.
@ast
A novel family of variable region genes of the human immunoglobulin heavy chain.
@en
prefLabel
A novel family of variable region genes of the human immunoglobulin heavy chain.
@ast
A novel family of variable region genes of the human immunoglobulin heavy chain.
@en
P2093
P1476
A novel family of variable region genes of the human immunoglobulin heavy chain.
@en
P2093
P304
P356
10.1016/0022-2836(87)90482-7
P407
P577
1987-06-01T00:00:00Z