Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.
about
The ABC protein turned chloride channel whose failure causes cystic fibrosisCFTR gating II: Effects of nucleotide binding on the stability of open statesCFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).The Nucleotide-Binding Sites of SUR1: A Mechanistic ModelStructure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulatorCrystal structure of a heterodimeric ABC transporter in its inward-facing conformationStructural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerizationDevelopment of CFTR StructureATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.CFTR and TNR-CFTR expression and function in the kidney.Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.The H-loop in the second nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator is required for efficient chloride channel closingStable ATP binding mediated by a partial NBD dimer of the CFTR chloride channelADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects.A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels.The block of CFTR by scorpion venom is state-dependentAn electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening.Modeling the conformational changes underlying channel opening in CFTRMutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gatingCysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation.Molecular modelling and molecular dynamics of CFTR.Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulatorAdenylate kinase activity in ABC transporters.Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.The CFTR ion channel: gating, regulation, and anion permeationTransmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsConformational changes in the catalytically inactive nucleotide-binding site of CFTR.A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.Dimer opening of the nucleotide binding domains of ABC transporters after ATP hydrolysis.
P2860
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P2860
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Prolonged nonhydrolytic intera ...... nd its role in channel gating.
@ast
Prolonged nonhydrolytic intera ...... nd its role in channel gating.
@en
type
label
Prolonged nonhydrolytic intera ...... nd its role in channel gating.
@ast
Prolonged nonhydrolytic intera ...... nd its role in channel gating.
@en
prefLabel
Prolonged nonhydrolytic intera ...... nd its role in channel gating.
@ast
Prolonged nonhydrolytic intera ...... nd its role in channel gating.
@en
P2860
P356
P1476
Prolonged nonhydrolytic intera ...... nd its role in channel gating.
@en
P2093
Claudia Basso
David C Gadsby
P2860
P304
P356
10.1085/JGP.200308798
P577
2003-09-01T00:00:00Z