Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. - Wikidata - awgldk - TriplyDB

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

http://www.wikidata.org/entity/Q36490482

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy A role for ATR in the DNA damage-induced phosphorylation of p53 The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1 Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53 MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation Human claspin is required for replication checkpoint control ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis ATR disruption leads to chromosomal fragmentation and early embryonic lethality Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.A novel protein activity mediates DNA binding of an ATR-ATRIP complex.Inhibition of the herpes simplex virus type 1 DNA polymerase induces hyperphosphorylation of replication protein A and its accumulation at S-phase-specific sites of DNA damage during infection.Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.Caffeine and human DNA metabolism: the magic and the mystery.ATM: a mediator of multiple responses to genotoxic stress.Mechanisms of switching on p53: a role for covalent modification?Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.Aspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damage ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast.Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress The DNA-damage response: new molecular insights and new approaches to cancer therapy

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P2860

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

http://www.wikidata.org/entity/Q36490482

description

1998 nî lūn-bûn

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1998年の論文

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年學術文章

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1998年學術文章

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1998年學術文章

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name

Protein kinase mutants of huma ...... cell cycle checkpoint control.

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Protein kinase mutants of huma ...... cell cycle checkpoint control.

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type

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Protein kinase mutants of huma ...... cell cycle checkpoint control.

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Protein kinase mutants of huma ...... cell cycle checkpoint control.

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prefLabel

Protein kinase mutants of huma ...... cell cycle checkpoint control.

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Protein kinase mutants of huma ...... cell cycle checkpoint control.

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PNAS.95.13.7445

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Proceedings of the National Academy of Sciences of the United States of America

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Protein kinase mutants of huma ...... cell cycle checkpoint control.

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P2093

A M Carr

http://www.w3.org/2001/XMLSchema#string

D R Herendeen

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J A Wright

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K S Keegan

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M F Hoekstra

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N J Bentley

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P2860

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

The Schizosaccharomyces pombe rad3 checkpoint gene

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints.

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5

Checkpoints: controls that ensure the order of cell cycle events

Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpoints.

Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis.

p53 point mutation in HPV negative human cervical carcinoma cell lines.

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Patrick Concannon

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13648799

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9636169

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22645

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