Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo - Wikidata - awgldk - TriplyDB

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

http://www.wikidata.org/entity/Q36666647

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Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition Threats to the mind: aging, amyloid, and hypertension Optogenetics for neurodegenerative diseases.Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity The role of APP and BACE1 trafficking in APP processing and amyloid-β generation Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes Dynamin 1 regulates amyloid generation through modulation of BACE-1 Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.On the central role of brain connectivity in neurodegenerative disease progression Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta Trafficking and proteolytic processing of APP Molecular mechanisms of cognitive dysfunction following traumatic brain injury APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease Neuronal clearance of amyloid-β by endocytic receptor LRP1.Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications.Amyloid-β metabolism in Niemann-Pick C disease models and patients.HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons Synaptic and endosomal localization of active gamma-secretase in rat brain.Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex

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P2860

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

http://www.wikidata.org/entity/Q36666647

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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type

label

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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prefLabel

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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J.NEURON.2008.02.003

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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David M Holtzman

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Deborah K Verges

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Floy R Stewart

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Guojun Bu

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Jae-Eun Kang

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John R Cirrito

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Luz M Silverio

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.

Alzheimer's disease: genes, proteins, and therapy

PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

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Steven Mennerick

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5452871

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2390913

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