Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
about
BRCA2 and homologous recombinationBRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damageHighlight: BRCA1 and BRCA2 proteins in breast cancerDeficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joiningThe Icelandic founder mutation BRCA2 999del5: analysis of expressionMolding BRCA2 function through its interacting partnersAnalysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signalsInhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancerSuppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancerVariation in cancer risks, by mutation position, in BRCA2 mutation carriers.Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response.Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.Functional assays for classification of BRCA2 variants of uncertain significance.BRCA2 and Smad3 synergize in regulation of gene transcription.Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletionsMethylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomasThe breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms.Chromosomal instability and cancer predisposition: insights from studies on the breast cancer susceptibility gene, BRCA2.BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription.Brca2 deficiency leads to T cell loss and immune dysfunction.Functional assays for BRCA1 and BRCA2.The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer.Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin.Restoration of CAPAN-1 cells with functional BRCA2 provides insight into the DNA repair activity of individuals who are heterozygous for BRCA2 mutations.Effect of the novel Moroccan BRCA1 and BRCA2 frameshift mutations.A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localizationDegradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implicationsFamilial breast/ovarian cancer and BRCA1/2 genetic screening: the role of immunohistochemistry as an additional method in the selection of patientsFunctional assays for analysis of variants of uncertain significance in BRCA2.BRCA2: one small step for DNA repair, one giant protein purified.Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins.Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation.Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity.Genome annotation by shotgun inactivation of a native gene in hemizygous cells: application to BRCA2 with implication of hypomorphic variants.
P2860
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P2860
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
@ast
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
@en
type
label
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
@ast
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
@en
prefLabel
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
@ast
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
@en
P2093
P2860
P356
P1476
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
@en
P2093
C J Larson
L S Shihabuddin
P2860
P304
13920-13925
P356
10.1073/PNAS.96.24.13920
P407
P577
1999-11-01T00:00:00Z