Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development - Wikidata - awgldk - TriplyDB

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

http://www.wikidata.org/entity/Q36745250

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Compromised HOXA5 function can limit p53 expression in human breast tumours Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells.Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein Homeobox genes in mammary gland development and neoplasia Chromatin signatures of cancer Genetic modifiers of MeCP2 function in Drosophila.The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1 COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1 Structure of AF3p21, a new member of mixed lineage leukemia (MLL) fusion partner proteins-implication for MLL-induced leukemogenesis.Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.Disordered epigenetic regulation in MLL-related leukemia.Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2.The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence.Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodeling.Molecular mechanisms underlying human synovial sarcoma development.Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia.Epigenetic modifications in pluripotent and differentiated cells.A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15.MLL fusion partners AF4 and AF9 interact at subnuclear foci.Homeobox genes in normal and malignant cells.Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

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Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

http://www.wikidata.org/entity/Q36745250

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Proceedings of the National Academy of Sciences of the United States of America

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Mammalian Trithorax and polyco ...... lators of homeotic development

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A Berns

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C S Shashikant

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F H Ruddle

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J L Hess

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M Seto

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M van Lohuizen

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S J Korsmeyer

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P2860

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres

Efficient selection for high-expression transfectants with a novel eukaryotic vector

Stage-specific expression of polycomb group genes in human bone marrow cells

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression

Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

Altered Hox expression and segmental identity in Mll-mutant mice

Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster

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