Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. - Wikidata - awgldk - TriplyDB

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.

http://www.wikidata.org/entity/Q36794017

about

Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms DISC1: a key lead in studying cortical development and associated brain disorders Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice DISC1 at 10: connecting psychiatric genetics and neuroscience DISC1-binding proteins in neural development, signalling and schizophrenia DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness Dixdc1 is a critical regulator of DISC1 and embryonic cortical development Discovering implicit entity relation with the gene-citation-gene network Phenomics: the systematic study of phenotypes on a genome-wide scale A genome-wide investigation of SNPs and CNVs in schizophrenia.708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system.Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding.The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain DISC1 in schizophrenia: genetic mouse models and human genomic imaging.The genetic interacting landscape of 63 candidate genes in Major Depressive Disorder: an explorative study.Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents.Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility.Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly.Copy number variations of chromosome 16p13.1 region associated with schizophrenia.The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.DISC1 genetics, biology and psychiatric illness Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness.Schizophrenia genomics and proteomics: are we any closer to biomarker discovery?Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.Candidate genes and their interactions with other genetic/environmental risk factors in the etiology of schizophrenia.Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics.Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.Common variants in psychiatric risk genes predict brain structure at birth.DISCopathies: brain disorders related to DISC1 dysfunction.Ndel1, Nudel (Noodle): flexible in the cell?Molecular links between mitochondrial dysfunctions and schizophrenia.DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders.High frequency of rare copy number variants affecting functionally related genes in patients with structural brain malformations.Regulation of neuronal migration, an emerging topic in autism spectrum disorders.

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Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.

http://www.wikidata.org/entity/Q36794017

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2008 nî lūn-bûn

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Elucidating the relationship b ...... tasis and competitive binding.

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Elucidating the relationship b ...... tasis and competitive binding.

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Elucidating the relationship b ...... tasis and competitive binding.

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Akira Sawa

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Anil K Malhotra

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Colin A Hodgkinson

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Hiroyuki Arai

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P2860

LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes

Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation

Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly

Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth

Inference of population structure using multilocus genotype data

Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1

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