Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells.
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Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.The tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein functionOverexpression of cyclin A inhibits augmentation of recombinant adeno-associated virus transduction by the adenovirus E4orf6 protein.Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.Adenovirus early region 4 stimulates mRNA accumulation via 5' introns.Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure.Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblastsExport of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor.Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism.An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression.Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids.Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.The C-terminal 70 amino acids of the adenovirus E4-ORF6/7 protein are essential and sufficient for E2F complex formationHuman adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cellsmRNA export correlates with activation of transcription in human subgroup C adenovirus-infected cellsAdenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisAdenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides.Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.Cell polarity proteins: common targets for tumorigenic human viruses.Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityAdenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsThe adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complexThe NFIII/OCT-1 binding site stimulates adenovirus DNA replication in vivo and is functionally redundant with adjacent sequencesAdenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transitionActivation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein.Defective synthesis of early region 4 mRNAs during abortive adenovirus infections in monkey cellsRUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisAdenovirus early region 4 is essential for normal stability of late nuclear RNAsRedundant control of adenovirus late gene expression by early region 4Intranuclear location of the adenovirus type 5 E1B 55-kilodalton protein.Ability of p53 and the adenovirus E1b 58-kilodalton protein to form a complex is determined by p53Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activity
P2860
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P2860
Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Analysis of adenovirus early r ...... n productively infected cells.
@en
type
label
Analysis of adenovirus early r ...... n productively infected cells.
@en
prefLabel
Analysis of adenovirus early r ...... n productively infected cells.
@en
P2093
P2860
P1433
P1476
Analysis of adenovirus early r ...... n productively infected cells.
@en
P2093
P2860
P304
P407
P577
1987-02-01T00:00:00Z