Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
about
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisMDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activityN-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responsesInhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.Wild type p53 reactivation: from lab bench to clinic.Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cellsInhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds.The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis.HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas.Targeting the ubiquitin-proteasome system for cancer therapyTargeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.Nutlin-3, A P53-Mdm2 Antagonist For Nasopharyngeal Carcinoma Treatment.5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.The Role of MDM2 in Promoting Genome Stability versus Instability.E3 ubiquitin ligases in cancer and implications for therapies.An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage.
P2860
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P2860
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
@en
type
label
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
@en
prefLabel
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
@en
P2093
P2860
P1476
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
@en
P2093
Allan M Weissman
Jirouta Kitagaki
Keli K Agama
P2860
P304
P356
10.1158/1535-7163.MCT-08-0063
P50
P577
2008-08-01T00:00:00Z