The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.
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Hematopoietic stem cell gene therapy:assessing the relevance of preclinical modelsEfficient human hematopoietic cell transduction using RD114- and GALV-pseudotyped retroviral vectors produced in suspension and serum-free media.Transduction of human primitive repopulating hematopoietic cells with lentiviral vectors pseudotyped with various envelope proteins.Isolation of stem cell-specific cDNAs from hematopoietic stem cell populations.Efficient transduction by an amphotropic retrovirus vector is dependent on high-level expression of the cell surface virus receptorHigh-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments.Cell-type-specific gene transfer into human cells with retroviral vectors that display single-chain antibodies.Avian reticuloendotheliosis virus strain A and spleen necrosis virus do not infect human cells.Retroviral vectors pseudotyped with lymphocytic choriomeningitis virus.Gene therapy for the hemoglobin disorders: past, present, and future.Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors.Large animal models of hematopoietic stem cell gene therapy.Entry of amphotropic and 10A1 pseudotyped murine retroviruses is restricted in hematopoietic stem cell lines.An all-feline retroviral packaging system for transduction of human cells.The use of nonhuman primate models to improve gene transfer into haematopoietic stem cells.Gammaretroviral vectors: biology, technology and applicationGene therapy to protect haematopoietic cells from cytotoxic cancer drugs.Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectorsParvovirus infection suppresses long-term repopulating hematopoietic stem cellsGenetic modification of human hematopoietic cells: preclinical optimization of oncoretroviral-mediated gene transfer for clinical trialsTransplantation of human umbilical cord blood cells in the repair of CNS diseases.Improved transduction of human sheep repopulating cells by retrovirus vectors pseudotyped with feline leukemia virus type C or RD114 envelopes.Lentivirus-mediated gene transfer to the respiratory epithelium: a promising approach to gene therapy of cystic fibrosis.Hematopoietic stem cell gene therapy with drug resistance genes: an update.Cell targeting in anti-cancer gene therapyReduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells.The Scope of Viral Vectors for the Transduction of Haemopoietic Cells.Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease.T-cell receptor transfer into human T cells with ecotropic retroviral vectors.Transduction of human embryonic stem cells by ecotropic retroviral vectors.Importance of receptor usage, Fli1 activation, and mouse strain for the stem cell specificity of 10A1 murine leukemia virus leukemogenicity.Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia.Toward a more accurate quantitation of the activity of recombinant retroviruses: alternatives to titer and multiplicity of infection.G100R mutation within 4070A murine leukemia virus Env increases virus receptor binding, kinetics of entry, and viral transduction efficiency.Envelope fusion protein binding studies in an inducible model of retrovirus receptor expression and in CD34(+) cells emphasize limited transduction at low receptor levels.Improved gene transfer into canine hematopoietic repopulating cells using CD34-enriched marrow cells in combination with a gibbon ape leukemia virus-pseudotype retroviral vector.Transplantation of transduced nonhuman primate CD34+ cells using a gibbon ape leukemia virus vector: restricted expression of the gibbon ape leukemia virus receptor to a subset of CD34+ cells.Rapid retroviral infection of human haemopoietic cells of different lineages: efficient transfer in fresh T cells.Amphotropic retrovirus transduction of hematopoietic stem cells.Genetic protection of repopulating hematopoietic cells with an improved MDR1-retrovirus allows administration of intensified chemotherapy following stem cell transplantation in mice.
P2860
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P2860
The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The level of mRNA encoding the ...... cy of retrovirus transduction.
@en
The level of mRNA encoding the ...... cy of retrovirus transduction.
@nl
type
label
The level of mRNA encoding the ...... cy of retrovirus transduction.
@en
The level of mRNA encoding the ...... cy of retrovirus transduction.
@nl
prefLabel
The level of mRNA encoding the ...... cy of retrovirus transduction.
@en
The level of mRNA encoding the ...... cy of retrovirus transduction.
@nl
P2093
P2860
P356
P1476
The level of mRNA encoding the ...... cy of retrovirus transduction.
@en
P2093
P2860
P304
11097-11102
P356
10.1073/PNAS.93.20.11097
P407
P577
1996-10-01T00:00:00Z