A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2.
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P1343
E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAsTransduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesisAnalysis of human cytomegalovirus oriLyt sequence requirements in the context of the viral genome.Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replicationIn vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted.An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein functionRole of adenovirus type 2 early region 4 in the early-to-late switch during productive infection.Sequence-specific trans-activation of the adenovirus EIIa early promoter by the viral EIV transcription unit.Expression of the adenovirus E4 34k oncoprotein inhibits repair of double strand breaks in the cellular genome of a 293-based inducible cell line.E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids.Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit.Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.Diminishing adenovirus gene expression and viral replication by promoter replacement.Recombinational construction in Escherichia coli of infectious adenoviral genomesIdentification of a new human adenovirus protein encoded by a novel late l-strand transcription unit.Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirus mutantsControl of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityA late adenovirus factor induces eIF-4E dephosphorylation and inhibition of cell protein synthesis.Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transitionActivation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1Adenovirus early region 4 is essential for normal stability of late nuclear RNAsRedundant control of adenovirus late gene expression by early region 4The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA.Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication.Characterization of adenovirus particles made by deletion mutants lacking the fiber gene.Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection.The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation.Concentration dependence of transcriptional transactivation in inducible E1A-containing human cellsAdenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff.Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expressionGene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides.Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells.Requirement for either early region 1a or early region 1b adenovirus gene products in the helper effect for adeno-associated virusmRNAs from human adenovirus 2 early region 4.
P2860
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P2860
A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A cell line that supports the ...... nt of human adenovirus type 2.
@en
A cell line that supports the ...... nt of human adenovirus type 2.
@nl
type
label
A cell line that supports the ...... nt of human adenovirus type 2.
@en
A cell line that supports the ...... nt of human adenovirus type 2.
@nl
prefLabel
A cell line that supports the ...... nt of human adenovirus type 2.
@en
A cell line that supports the ...... nt of human adenovirus type 2.
@nl
P2860
P356
P1476
A cell line that supports the ...... nt of human adenovirus type 2.
@en
P2093
D H Weinberg
P2860
P304
P356
10.1073/PNAS.80.17.5383
P407
P4510
P577
1983-09-01T00:00:00Z