Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?
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Isoform-specific enhancement of adenylyl cyclase activity by n-alkanolsGeneral anaesthetic actions on ligand-gated ion channelsA discrete alcohol pocket involved in GIRK channel activationMolecular and Integrative Physiological Effects of Isoflurane Anesthesia: The Paradigm of Cardiovascular Studies in Rodents using Magnetic Resonance ImagingStructure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogasterThe Role of Multiple Hydrogen-Bonding Groups in Specific Alcohol Binding Sites in Proteins: Insights from Structural Studies of LUSHThe actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutationsMethionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anestheticsStraight-chain alcohols exhibit a cutoff in potency for the inhibition of recombinant glutamate receptor subunitsGeneral anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channelG-protein-coupled inwardly rectifying potassium channels are targets of alcohol actionEthanol opens G-protein-activated inwardly rectifying K+ channelsDirect evidence for a cause-effect link between ethanol potentiation of GABA(A) receptor function and intoxication from hyperbaric studies in C57, LS, and SS mice.Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors.A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progressLow dose acute alcohol effects on GABA A receptor subtypesMolecular targets and mechanisms for ethanol action in glycine receptorsCompeting interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptorsMitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injuryA transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4.Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains.Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation.Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion.Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes.A single amino acid confers barbiturate sensitivity upon the GABA rho 1 receptorTryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.Inhibition of glycine receptor function of native neurons by aliphatic n-alcohols.Mutations of L293 in transmembrane two of the mouse 5-hydroxytryptamine3A receptor alter gating and alcohol modulatory actionsAntagonists of alcohol inhibition of cell adhesion.Structural basis for alcohol modulation of a pentameric ligand-gated ion channelFunctional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.Are sobriety and consciousness determined by water in protein cavities?Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors.Different sites of alcohol action in the NMDA receptor GluN2A and GluN2B subunits.
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P2860
Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1998
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mutations of gamma-aminobutyri ...... dence for an alcohol receptor?
@en
Mutations of gamma-aminobutyri ...... dence for an alcohol receptor?
@nl
type
label
Mutations of gamma-aminobutyri ...... dence for an alcohol receptor?
@en
Mutations of gamma-aminobutyri ...... dence for an alcohol receptor?
@nl
prefLabel
Mutations of gamma-aminobutyri ...... dence for an alcohol receptor?
@en
Mutations of gamma-aminobutyri ...... dence for an alcohol receptor?
@nl
P2093
P2860
P356
P1476
Mutations of gamma-aminobutyri ...... dence for an alcohol receptor?
@en
P2093
J R Trudell
M P Mascia
N L Harrison
R A Harris
S J Brozowski
P2860
P304
P356
10.1073/PNAS.95.11.6504
P407
P577
1998-05-01T00:00:00Z