Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
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Kir6.2 is required for adaptation to stress.TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretionNoc2 is essential in normal regulation of exocytosis in endocrine and exocrine cellsRequirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generationThe A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channelMitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytesImmunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculatureCritical role of gap junction coupled KATP channel activity for regulated insulin secretionCarbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1Physiological consequences of complex II inhibition for aging, disease, and the mKATP channelTissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemiaDynamic activation of K(ATP) channels in rhythmically active neuronsChronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cellsCritical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretionFoxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin releaseExpression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heartThe MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model SystemsR-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretionCardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation.Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.Hyperinsulinism induced by targeted suppression of beta cell KATP channels.BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures.Purinergic contribution to circulatory, metabolic, and adrenergic responses to acute hypoxemia in fetal sheep.Why treatment fails in type 2 diabetesATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility.Hyperinsulinism of infancy: towards an understanding of unregulated insulin release. European Network for Research into Hyperinsulinism in Infancy.Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload.Ions, genes and insulin release: from basic science to clinical disease. Based on the 1998 R. D. Lawrence Lecture.ATP-sensitive potassium channelopathies: focus on insulin secretionRegulation of insulin secretion: role of mitochondrial signalling.Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscleDiazoxide, a K(ATP) channel opener, prevents ischemia-reperfusion injury in rodent pancreatic islets.Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell.Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Calcium-stimulated insulin secretion in diffuse and focal forms of congenital hyperinsulinism.Genetic manipulation of insulin signaling, action and secretion in mice. Insights into glucose homeostasis and pathogenesis of type 2 diabetes.Pharmacogenetics of Anti-Diabetes Drugs.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling
P2860
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P2860
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
@en
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
@nl
type
label
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
@en
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
@nl
prefLabel
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
@en
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
@nl
P2093
P2860
P356
P1476
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice
@en
P2093
A Tamamoto
H Yoshitomi
K Nagashima
P2860
P304
10402-10406
P356
10.1073/PNAS.95.18.10402
P407
P577
1998-09-01T00:00:00Z