Calf 5' to 3' exo/endonuclease must slide from a 5' end of the substrate to perform structure-specific cleavage.
about
Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repairMolecular interactions of human Exo1 with DNAArginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determinationStructural determinants for substrate binding and catalysis by the structure-specific endonuclease XPGWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkHuman exonuclease 5 is a novel sliding exonuclease required for genome stabilityBiochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1Essential amino acids for substrate binding and catalysis of human flap endonuclease 1Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigenIdling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replicationComponents of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processingAn alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicasePolymerase dynamics at the eukaryotic DNA replication forkLong patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complexThe 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysisDouble strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamilyUnpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleasesMolecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshiiCrystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substratesStructure of flap endonuclease 1 from the hyperthermophilic archaeonDesulfurococcus amylolyticusThe crystal structure of flap endonuclease-1 from Methanococcus jannaschiiMutagenesis of conserved lysine residues in bacteriophage T5 5'-3' exonuclease suggests separate mechanisms of endo-and exonucleolytic cleavageSaccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nucleaseDna2 exhibits a unique strand end-dependent helicase function.Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential functionReconstituted Okazaki fragment processing indicates two pathways of primer removal.Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation.Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulationOkazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nickProliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stageEnzymes and reactions at the eukaryotic DNA replication forkMechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1Quantification of protein group coherence and pathway assignment using functional association.The protein components and mechanism of eukaryotic Okazaki fragment maturation.On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing.Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Characterization of FEN-1 from Xenopus laevis. cDNA cloning and role in DNA metabolism.
P2860
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P2860
Calf 5' to 3' exo/endonuclease must slide from a 5' end of the substrate to perform structure-specific cleavage.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Calf 5' to 3' exo/endonuclease ...... m structure-specific cleavage.
@en
type
label
Calf 5' to 3' exo/endonuclease ...... m structure-specific cleavage.
@en
prefLabel
Calf 5' to 3' exo/endonuclease ...... m structure-specific cleavage.
@en
P2093
P2860
P356
P1476
Calf 5' to 3' exo/endonuclease ...... m structure-specific cleavage.
@en
P2093
P2860
P304
30377-30383
P356
10.1074/JBC.270.51.30377
P407
P577
1995-12-01T00:00:00Z